34058-54-3

Basic information

• Product Name: 2-PHENYL-1H-INDOLE-4-CARBOXYLIC ACID METHYL ESTER
• Synonyms: 1H-INDOLE-4-CARBOXYLIC ACID, 2-PHENYL-, METHYL ESTER;2-PHENYL-1H-INDOLE-4-CARBOXYLIC ACID METHYL ESTER
• CAS NO: 34058-54-3
• Molecular Formula: C₁₆H₁₃NO₂
• Molecular Weight: 251.284
• Mol File: 34058-54-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-PHENYL-1H-INDOLE-4-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-1H-INDOLE-4-CARBOXYLIC ACID METHYL ESTER(34058-54-3)
• EPA Substance Registry System: 2-PHENYL-1H-INDOLE-4-CARBOXYLIC ACID METHYL ESTER(34058-54-3)

Safety Data

• Hazardous Substances Data: 34058-54-3(Hazardous Substances Data)

Upstream product

• 106896-48-4 methyl 2-bromo-3-aminobenzoate 
• 14990-66-0 1-(1-phenylvinyl)piperidine 
• 39830-66-5 methyl 1H-indole-4-carboxylate 
• 618-41-7 Benzenesulfinic acid 
• 873-55-2 sodium benzenesulfonate 
• 98-80-6 phenylboronic acid 
• 80-17-1 benzenesufonyl hydrazide 

Relevant articles and documents

Well-defined (NHC)Pd(N–heterocyclic carboxylate)(OAc) complexes-catalyzed direct C2-arylation of free (NH)-indoles with arylsulfonyl hydrazides

A series of well-defined (NHC)Pd(N–heterocyclic carboxylate)(OAc) complexes (N–heterocyclic carboxylate = pyridine-2-carboxylate, quinoline-2-carboxylate and isoquinoline-1-carboxylate) were synthesized and fully characterized by NMR spectra, HR-MS and X-ray single crystal diffraction. The obtained complexes were then used for direct C2-arylation of free (NH)-indoles with arylsulfonyl hydrazides. With low catalyst loading, all complexes exhibited high catalytic activities for the arylation reactions.

Microwave-accelerated Pd-catalyzed desulfitative direct C2-arylation of free (NH)-indoles with arylsulfinic acids

The rapid and efficient direct C2-arylation of free (NH)-indoles with arylsulfinic acids proceeded through a microwave-accelerated palladium-catalyzed desulfitation reaction. By using PdCl2 as a catalyst, silver acetate as an oxidant, and H2SO4 as an additive, arylsulfinic acids with both electron-donating and electron-withdrawing groups underwent desulfitative coupling with an array of free (NH)-indoles, thereby selectively providing C2-arylindoles in good yields. From C2 shining sea: The direct C2-arylation of free (NH)-indoles with arylsulfinic acids proceeded through a Pd-catalyzed desulfitation reaction. In the presence of an oxidant and an additive, 2-arylindoles were selectively afforded in good yields. Copyright

Synthesis of Indole Derivatives from 2-Bromoanilines by a Palladium-assisted Reaction

In the presence of palladium(II) acetate, 2-bromoanilines readily react with enamines such as N-vinylpyrrolidone or α-piperidinostyrene to produce indole derivatives.