106970-98-3Relevant articles and documents
Phase-Transfer Catalyzed Asymmetric [4 + 1] Annulations for the Synthesis of Chiral 2,2-Disubstituted Tetrahydrothiophenes
Yin, Qi,Wen, Xiaolu,Chen, Yiwei,Gong, Xiangnan,Hu, Lin
, p. 7529 - 7534 (2021/10/02)
An efficient catalytic asymmetric [4 + 1] reaction, which features the use of simple β-keto esters as one-carbon nucleophiles and 5-succinimidothio-pent-2-enoates as four-atom bielectrophiles, has been developed in the presence of a bifunctional chiral ph
Synthesis of the 1,3,4-Oxadiazole Core through Thermolysis of Geminal Diazides
Erhardt, Hellmuth,Mohr, Fabian,Kirsch, Stefan F.
supporting information, p. 5629 - 5632 (2016/12/14)
The thermolysis of geminal diazides derived from acylacetate compounds is an efficient tool for the rapid construction of the 1,3,4-oxadiazole core. While a broad range of ethyl esters undergoes smooth transformation to the desired heterocycles that contain the ester moiety in moderate to high yields, the analogous tert-butyl esters give rise to the oxadiazoles with acyl groups, presumably through a pathway of decarboxylation followed by a new acyl transfer.
Regioselective synthesis of highly aryl-substituted pyrrole carboxylates as useful medicinal chemistry leads
Bhatt, Ulhas,Duffy, Bryan C.,Guzzo, Peter R.,Cheng, Leifeng,Elebring, Thomas
, p. 2793 - 2806 (2008/02/12)
The regioselective syntheses of two pharmaceutically relevant pyrrole scaffolds are described. A synthetic route for the preparation of differentially substituted pyrrole-3,4-dicarboxylates is presented and exemplified. This route circumvents some of the
