107036-54-4

Basic information

• Product Name: 3'-deoxy-5'-O-triphenylmethylthymidine
• Synonyms: 3'-deoxy-5'-O-triphenylmethylthymidine
• CAS NO: 107036-54-4
• Molecular Weight: 468.552
• Mol File: 107036-54-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3'-deoxy-5'-O-triphenylmethylthymidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-deoxy-5'-O-triphenylmethylthymidine(107036-54-4)
• EPA Substance Registry System: 3'-deoxy-5'-O-triphenylmethylthymidine(107036-54-4)

Safety Data

• Hazardous Substances Data: 107036-54-4(Hazardous Substances Data)

Upstream product

• 1140622-67-8 3'-O-[(propylthio)thiocarbonyl]-5'-O-triphenylmethylthymidine 
• 7791-71-1 5'-O-tritylthymidine 
• 107036-53-3 3'-O-(1-imidazolylthiocarbonyl)-5'-O-tritylthymidine 
• 123884-06-0 3'-O-(phenoxythiocarbonyl)-5'-O-tritylthymidine 

Downstream Products

• 107036-56-6 2',3'-dideoxy-5-methylcytidine 
• 3416-05-5 3'-Deoxythymidine 
• 107036-55-5 2',3'-dideoxy-5'-O-(tritylribosyl)-5-methyl-4-(1,2,4-triazol-1-yl)pyrimidin-2-one 

Relevant articles and documents

Protecting groups transfer: Unusual method of removal of tr and TBDMS groups by transetherification

The triphenylmethyl (Tr) group undergoes a transfer (transetherification or disproportionation) between the molecules of 5'-O-Tr-2'-deoxynucleosides in a process mediated by anhydrous sulfates of Cu+2, Fe+2, or Ni+2 to yield mixtures of 3',5'-bis-O-Tr and 3'-O-Tr products. If phenylmethanol is present in a reaction medium, detritylation results with concomitant formation of phenylmethyl triphenylmethyl ether. The behavior of t-butyldimethylsilyl (TBDMS) group in 5'-O-TBDMS-2'-deoxynucleosides is exactly the same. Such type of transetherifications was not observed before for the O-Tr and O-TBDMS groups. Copyright Taylor & Francis Group, LLC.

Potent Anti-AIDS Drugs. 2',3'-Dideoxycytidine Analogues

5-Substituted 2',3'-dideoxycytidine analogues have been synthesized and evaluated in vitro for their capabilities to protect T4+ lymphocytes from the cytopathic effects of the HTLV-III/LAV (HIV) virus, the causative agent of acquired immunodefi