3416-05-5 Usage
Description
2',3'-Dideoxythymidine, also known as 3'-Deoxythymidine, is a thymidine derivative with a modified sugar moiety where the 2' and 3' hydroxyl groups are replaced by hydrogen atoms. This modification makes it a potent inhibitor of various viral and cellular enzymes involved in nucleic acid synthesis. It has gained significant attention in the fields of virology and oncology due to its potential therapeutic applications.
Uses
Used in Antiviral Applications:
2',3'-Dideoxythymidine is used as an antiviral agent for inhibiting the replication of certain viruses, such as the bacteriophage T7, by blocking the synthesis of phage DNA. This property makes it a valuable research tool for studying the mechanisms of viral replication and the development of antiviral therapies.
Used in Anticancer Applications:
In the field of oncology, 2',3'-Dideoxythymidine serves as a precursor for the development of DNA polymerase β inhibitors. These inhibitors have the potential to disrupt the DNA synthesis process in cancer cells, thereby inhibiting their proliferation and growth. This application highlights the compound's utility in the research and development of novel anticancer drugs.
Used in Research and Development:
2',3'-Dideoxythymidine is also employed as a research tool for studying the mechanisms of action of various antiviral and anticancer agents. Its unique structure allows scientists to investigate the interactions between nucleic acids and enzymes, as well as the development of new strategies for targeting viral and cancerous cells. This application further underscores the compound's importance in advancing our understanding of viral and cancer biology and the development of effective therapeutic interventions.
Purification Methods
3'-Deoxyuridine is recrystallised from Me2CO/MeOH and is dried in a vacuum. [Michelson & Todd J Chem Soc 816 1955.]
Check Digit Verification of cas no
The CAS Registry Mumber 3416-05-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,4,1 and 6 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 3416-05:
(6*3)+(5*4)+(4*1)+(3*6)+(2*0)+(1*5)=65
65 % 10 = 5
So 3416-05-5 is a valid CAS Registry Number.
3416-05-5Relevant articles and documents
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Wempen,I.,Fox,J.J.
, p. 1020 - 1025 (1969)
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NMR studies of pyrimidinic nucleosides derived from 2,3-dideoxy-d-ribose with inhibitory activity on LINE-1 mobility
Banuelos-Sanchez, Guillermo,Franco-Montalban, Francisco,Tamayo, Juan A.
, p. 118 - 125 (2019/11/28)
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Synthesis of C3′ modified nucleosides for selective generation of the C3′-deoxy-3′-thymidinyl radical: A proposed intermediate in LEE induced DNA damage
Audat, Suaad A. S.,Trzasko Love, Cherylann,Al-Oudat, Buthina A. S.,Bryant-Friedrich, Amanda C.
experimental part, p. 3829 - 3837 (2012/06/29)
DNA damage pathways induced by low-energy electrons (LEEs) are believed to involve the formation of 2-deoxyribose radicals. These radicals, formed at the C3′ and C5′ positions of nucleotides, are the result of cleavage of the C-O phosphodiester bond throu