164905-37-7

Basic information

• Product Name: [Hydroxy-(4-methoxy-phenyl)-methyl]-phosphonic acid bis-[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester
• Synonyms: [Hydroxy-(4-methoxy-phenyl)-methyl]-phosphonic acid bis-[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester
• CAS NO: 164905-37-7
• Molecular Weight: 634.58
• Mol File: 164905-37-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [Hydroxy-(4-methoxy-phenyl)-methyl]-phosphonic acid bis-[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester(CAS DataBase Reference)
• NIST Chemistry Reference: [Hydroxy-(4-methoxy-phenyl)-methyl]-phosphonic acid bis-[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester(164905-37-7)
• EPA Substance Registry System: [Hydroxy-(4-methoxy-phenyl)-methyl]-phosphonic acid bis-[(2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester(164905-37-7)

Safety Data

• Hazardous Substances Data: 164905-37-7(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 155185-25-4 5',5'-O-(2',3'-Didesoxythymidin)-H-phosphonatdiester 
• 3416-05-5 3'-Deoxythymidine 

Downstream Products

• 123-11-5 4-methoxy-benzaldehyde 
• 155185-25-4 5',5'-O-(2',3'-Didesoxythymidin)-H-phosphonatdiester 
• 3416-05-5 3'-Deoxythymidine 

Relevant articles and documents

Homo dinucleoside-α-hydroxyphosphonate diesters as prodrugs of the antiviral nucleoside analogues 2',3'-dideoxythymidine and 3'-azido-2',3'- dideoxythymidine

The synthesis of a new prodrug system for antiviral nucleosides AZT (1) and ddT (2) based on α-hydroxyhenzylphosphonates 3 is described. 3 hydrolyze via different mechanisms yielding the H-phosphonate monoesters 4 or nucleoside monophosphates 5, respectively, 3 were more lipophilic than 1, 2 and showed marked activity against HIV-1/2.