107202-32-4

Basic information

• Product Name: (S)-2-Amino-4-cyclohexyl-butan-1-ol
• Synonyms: (S)-2-Amino-4-cyclohexyl-butan-1-ol
• CAS NO: 107202-32-4
• Molecular Weight: 171.283
• Mol File: 107202-32-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-2-Amino-4-cyclohexyl-butan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-Amino-4-cyclohexyl-butan-1-ol(107202-32-4)
• EPA Substance Registry System: (S)-2-Amino-4-cyclohexyl-butan-1-ol(107202-32-4)

Safety Data

• Hazardous Substances Data: 107202-32-4(Hazardous Substances Data)

Upstream product

• 46460-23-5 ethyl 2-amino-4-phenyl-(2S)-butyrate 
• 107202-31-3 (S)-2-amino-4-cyclohexylbutyric acid hydrochloride 

Downstream Products

• 107202-60-8 ((S)-3-Cyclohexyl-1-(S)-oxiranyl-propyl)-carbamic acid tert-butyl ester 
• 107202-59-5 ((S)-3-Cyclohexyl-1-(R)-oxiranyl-propyl)-carbamic acid tert-butyl ester 
• 666718-95-2 ((S)-3-Cyclohexyl-1-formyl-propyl)-carbamic acid tert-butyl ester 
• 107202-45-9 (S)-3-(t-boc-amino)-1-cyclohexylpent-4-ene 
• 107202-35-7 (S)-2-(t-boc-amino)-4-cyclohexylbutan-1-ol 

Relevant articles and documents

Catalytic Hydrogenation of Chiral α-Amino and α-Hydroxy Esters at Room Temperature with Nishimura Catalyst without Racemization

The hydrogenation of carboxylic acid derivatives at room temperature was investigated. With a mixed Rh/Pt oxide (Nishimura catalyst), low to medium activity was observed for various α-amino and α-hydroxy esters. At 100 bar hydrogen pressure and 10% catalysts loading, high yields of the desired amino alcohols and diols were obtained without racemization. The most suitable α-substituents were NH2, NHR, and OH, whereas β-NH2 were less effective. Usually, aromatic rings were also hydrogenated, but with the free bases of amino acids as substrates, some selectivity was observed. No reaction was found for α-NR2, α-OR, and unfunctionalized esters; acids and amides were also not reduced under these conditions. A working hypothesis for the mode of action of the catalyst is presented.