107779-48-6

Basic information

• Product Name: N-(1-(3,4-dimethoxyphenyl)propan-2-yl)-4-methylbenzenesulfonamide
• Synonyms: N-(1-(3,4-dimethoxyphenyl)propan-2-yl)-4-methylbenzenesulfonamide
• CAS NO: 107779-48-6
• Molecular Weight: 349.451
• Mol File: 107779-48-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(1-(3,4-dimethoxyphenyl)propan-2-yl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-(3,4-dimethoxyphenyl)propan-2-yl)-4-methylbenzenesulfonamide(107779-48-6)
• EPA Substance Registry System: N-(1-(3,4-dimethoxyphenyl)propan-2-yl)-4-methylbenzenesulfonamide(107779-48-6)

Safety Data

• Hazardous Substances Data: 107779-48-6(Hazardous Substances Data)

Upstream product

• 5460-32-2 1-iodo-3,4-dimethoxybenzene 
• 25856-77-3 1-tosyl-2-methylaziridine 
• 98-59-9 p-toluenesulfonyl chloride 
• 103798-63-6 (S)-1-(3,4-dimethoxy-phenyl)-2-(toluene-4-sulfonylamino)-3-(toluene-4-sulfonyloxy)-propane 
• 64778-78-5 (R)-3,4-dimethoxy-α-methylbenzeneethanamine 

Relevant articles and documents

Synthesis of β-Phenethylamines via Ni/Photoredox Cross-Electrophile Coupling of Aliphatic Aziridines and Aryl Iodides

A photoassisted Ni-catalyzed reductive cross-coupling between tosyl-protected alkyl aziridines and commercially available (hetero)aryl iodides is reported. This mild and modular method proceeds in the absence of stoichiometric heterogeneous reductants and uses an inexpensive organic photocatalyst to access medicinally valuable β-phenethylamine derivatives. Unprecedented reactivity was achieved with the activation of cyclic aziridines. Mechanistic studies suggest that the regioselectivity and reactivity observed under these conditions are a result of nucleophilic iodide ring opening of the aziridine to generate an iodoamine as the active electrophile. This strategy also enables cross-coupling with Boc-protected aziridines.