64778-78-5

Basic information

• Product Name: (R)-1-(3,4-DIMETHOXYPHENYL) 2-PROPANAMINE
• Synonyms: (R)-1-(3,4-DIMETHOXYPHENYL)-2-AMINOPROPANE;(R)-1-(3,4-DIMETHOXYPHENYL) 2-PROPANAMINE;(R)-1-Methyl-2-(3,4-dimethoxyphenyl)ethylamine;(R)-2-Amino-1-(3,4-dimethoxyphenyl)propane;(R)-3,4-Dimethoxyamphetamine
• CAS NO: 64778-78-5
• Molecular Formula: C₁₁H₁₇NO₂
• Molecular Weight: 195.26
• Mol File: 64778-78-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 288.967 °C at 760 mmHg
• Flash Point: 139.809 °C
• Appearance: /
• Density: 1.023 g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.512
• CAS DataBase Reference: (R)-1-(3,4-DIMETHOXYPHENYL) 2-PROPANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(3,4-DIMETHOXYPHENYL) 2-PROPANAMINE(64778-78-5)
• EPA Substance Registry System: (R)-1-(3,4-DIMETHOXYPHENYL) 2-PROPANAMINE(64778-78-5)

Safety Data

• Hazardous Substances Data: 64778-78-5(Hazardous Substances Data)

Usage

General Description

(R)-1-(3,4-Dimethoxyphenyl) 2-propanamine is a chemical compound with the molecular formula C11H17NO2. It is a chiral amine with a substituted phenyl ring and a propylamine chain. (R)-1-(3,4-DIMETHOXYPHENYL) 2-PROPANAMINE is commonly used in the synthesis of pharmaceuticals and bioactive compounds, as its chiral nature makes it useful for creating enantiomerically pure products. It has also been studied for its potential use as a precursor in the production of various drugs and biologically active compounds, due to its unique structural properties. Additionally, this compound has been investigated for its role in the treatment of certain medical conditions, including as a potential anti-inflammatory and antifungal agent.

InChI:InChI=1/C11H17NO2/c1-8(12)6-9-4-5-10(13-2)11(7-9)14-3/h4-5,7-8H,6,12H2,1-3H3/t8-/m1/s1

Upstream product

• 100388-95-2 (R)-3-(3,4-dimethoxy-phenyl)-2-methyl-propionyl chloride 
• 186581-53-3 diazomethane 
• 2410-01-7 (-)(D)-2-<3,4-Dihydroxy-phenyl>-1-methyl-aethylamin 
• 105779-71-3 (S)-(-)-[2-(3,4-dimethoxyphenyl)-1-hydroxymethylethyl]carbamic acid tert-butyl ester 
• 138908-56-2 (S)-(+)-2-tert-butoxycarbonylamino-3-(3,4-dimethoxyphenyl)propionic acid methyl ester 
• 138908-57-3 (S)-2-((tert-butoxycarbonyl)amino)-3-(3,4-dimethoxyphenyl)propyl methanesulfonate 
• 120-26-3 2-(3,4-dimethoxyphenyl)-1-methylethylamine 
• 776-99-8 3,4-dimethoxyphenylacetone 
• 97-53-0 4-allylguaiacol 
• 93-15-2 1,2-dimethoxy-4-(2-propenyl)benzene 
• 121-33-5 vanillin 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 107779-48-6 N-[(R)-2-(3,4-dimethoxy-phenyl)-1-methyl-ethyl]-toluene-4-sulfonamide 
• 142796-55-2 (R)-1-(3-Chloro-phenyl)-2-[(R)-2-(3,4-dimethoxy-phenyl)-1-methyl-ethylamino]-ethanol 
• 142796-56-3 (R)-5-(3-Chloro-phenyl)-3-[(R)-2-(3,4-dihydroxy-phenyl)-1-methyl-ethyl]-oxazolidin-2-one 
• 138908-58-4 [R-(R*,R*)]-5-(3-chlorophenyl)-3-[2-(3,4-dimethoxylphenyl)-1-methyl-ethyl]-oxazolidin-2-one 
• 139013-14-2 5-{(R)-2-[(R)-5-(3-Chloro-phenyl)-2-oxo-oxazolidin-3-yl]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid diethyl ester 
• 138908-40-4 CL 316243 
• 174336-36-8 (R)-N-(3,4-dimethoxybenzyl)-1-(3,4-dimethoxyphenyl)-prop-2-ylamine 
• 51-79-6 urethane 
• 94564-16-6 (R)-1-<2-(3,4-Dimethoxyphenyl)-1-methylethyl>pyrimidin-2,4,6(1H,3H,5H)-trion 
• 1446877-09-3 (R)-ethyl 1-(3,4-dimethoxyphenyl)propan-2-ylcarbamate 
• 1446877-11-7 (1S,3R)-1-(3-hydroxybenzyl)-6,7-dimethoxy-2,3-dimethyl-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Transaminase-mediated synthesis of enantiopure drug-like 1-(3′,4′-disubstituted phenyl)propan-2-amines

Transaminases (TAs) offer an environmentally and economically attractive method for the direct synthesis of pharmaceutically relevant disubstituted 1-phenylpropan-2-amine derivatives starting from prochiral ketones. In this work, we report the application of immobilised whole-cell biocatalysts with (R)-transaminase activity for the synthesis of novel disubstituted 1-phenylpropan-2-amines. After optimisation of the asymmetric synthesis, the (R)-enantiomers could be produced with 88-89% conversion and >99% ee, while the (S)-enantiomers could be selectively obtained as the unreacted fraction of the corresponding racemic amines in kinetic resolution with >48% conversion and >95% ee. This journal is

Enantiomeric separation of Novel Psychoactive Substances by capillary electrophoresis using (+)-18-crown-6-tetracarboxylic acid as chiral selector

In the recent years, hundreds of Novel Psychoactive Substances (NPS) have entered both the European and the global drug market. These drugs, which are mainly used for recreational matters, have caused serious social problems. Every year, the spectrum of these misused drugs is enlarged by new derivatives, which are produced by modifications of basic structures of already well-known substances. Additionally, a lot of them possess a stereogenic center which leads to 2 enantiomeric forms. The fact that the pharmacological effects and potencies of the enantiomers of these chiral NPS may differ can be assumed from a broad spectrum of active pharmaceutical ingredients. For this reason, analytical method development regarding enantiomeric separation for these classes of substances is of great pharmaceutical and medical interest. The aim of this work was to create an easy-to-prepare chiral capillary electrophoresis method for the enantioseparation of NPS which contains a primary amino group by means of (+)-18-crown-6-tetracarboxylic acid as chiral selector. Novel Psychoactive Substances were purchased at various Internet stores or represent samples seized by Austrian police. The effects of selector concentration, the electrolyte composition, and the addition of organic modifiers to the background electrolyte on enantioseparation were investigated. Under optimized conditions, the use of 20-mM (+)-18-crown-6-tetracarboxylic acid, 10-mM Tris, and 30-mM citric acid buffer at pH 2.10 turned out to be effective. Fifteen of 24 tested NPS were resolved in their enantiomers within 15?minutes. It was found that all NPS were traded as racemic mixtures.

Disodium (R,R)-5-amino>propyl>-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A Potent β-Adrenergic Agonist Virtually Specific for β3 Receptors. A Promising Antidiabetic and Antiobesity Agent

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