1446877-11-7Relevant articles and documents
Controlling stereoselectivity by enzymatic and chemical means to access enantiomerically pure (1S,3R)-1-benzyl-2,3-dimethyl-1,2,3,4- tetrahydroisoquinoline derivatives
Orden, Alejandro A.,Schrittwieser, Joerg H.,Resch, Verena,Mutti, Francesco G.,Kroutil, Wolfgang
, p. 744 - 749 (2013/07/25)
A chemoenzymatic strategy for the synthesis of enantiomerically pure novel alkaloids (1S,3R)-1-benzyl-2,3-dimethyl-1,2,3,4-tetrahydroisoquinolines is presented. The key steps are the biocatalytic stereoselective reductive amination of substituted 1-phenyl