138908-40-4 Usage
Description
CL 316243, also known as CL 316,243 Disodium Salt, is a potent and highly selective β3-adrenoceptor agonist. It is a synthetic compound that has been developed for its ability to target and activate the β3-adrenergic receptors, which play a crucial role in various physiological processes.
Uses
Used in Pharmaceutical Research:
CL 316243 is used as a β-agonist for injecting mice and studying its effect on the expression of mammalian major facilitator superfamily domain-containing protein (Mfsd2a). This application helps researchers understand the role of β3-adrenergic receptors in protein expression and their potential implications in various diseases.
Used in Metabolic Research:
CL 316243 is used as an adrenergic agonist to stimulate adrenergic response in order to study the metabolic activity of brown, beige, and white adipose tissues in mice. This application aids in understanding the role of β3-adrenergic receptors in energy metabolism and their potential as targets for obesity and metabolic disorders.
Used in Lipolytic Challenge Studies:
CL 316243 is used as a β3-adrenergic agonist to inject mice for in vivo lipolytic challenge. This application helps researchers investigate the effects of β3-adrenergic receptor activation on lipid metabolism and its potential role in the development of treatments for obesity and related metabolic disorders.
Hazard
A poison.
Biochem/physiol Actions
β Adrenoceptor is expressed in a number of tissues such as heart, adipose tissue, colon and other tissues. It is associated with many different biological functions. β Adrenoceptor fills in as an objective for treating type 2 diabetes, heart failure, cachexia, obesity, metabolic disorder, issues related with bladder, colon and malignant tumor growth. Depression and anxiety can also be treated via β adrenoceptor. CL 316,243 is known to have antidiabetic action via β adrenoceptor. It is a potent stimulator of lipolysis. It also activates β3- adrenoceptors on neurons in hypothalamic areas that are important in the central regulation of appetite.
Check Digit Verification of cas no
The CAS Registry Mumber 138908-40-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,8,9,0 and 8 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 138908-40:
(8*1)+(7*3)+(6*8)+(5*9)+(4*0)+(3*8)+(2*4)+(1*0)=154
154 % 10 = 4
So 138908-40-4 is a valid CAS Registry Number.
InChI:InChI=1/C20H20ClNO7.2Na/c1-11(22-10-15(23)13-3-2-4-14(21)9-13)7-12-5-6-16-17(8-12)29-20(28-16,18(24)25)19(26)27;;/h2-6,8-9,11,15,22-23H,7,10H2,1H3,(H,24,25)(H,26,27);;/t11-,15+;;/m1../s1
138908-40-4Relevant articles and documents
Disodium (R,R)-5-amino>propyl>-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A Potent β-Adrenergic Agonist Virtually Specific for β3 Receptors. A Promising Antidiabetic and Antiobesity Agent
Bloom, Jonathan D.,Dutia, Minu D.,Johnson, Bernard D.,Wissner, Allan,Burns, Michael G.,et al.
, p. 3081 - 3084 (2007/10/02)
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Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles
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, (2008/06/13)
The present invention discloses substituted 1,3-benzodioxoles which possess anti-diabetic and/or anti-hyperglycemic and/or anti-obesity properties in humans and other animals.
