1079366-88-3

Basic information

• Product Name: (R)-2-phenyl-1-(toluene-4-sulfonyl)azetidine
• Synonyms: (R)-2-phenyl-1-(toluene-4-sulfonyl)azetidine
• CAS NO: 1079366-88-3
• Molecular Weight: 287.382
• Mol File: 1079366-88-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-2-phenyl-1-(toluene-4-sulfonyl)azetidine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-phenyl-1-(toluene-4-sulfonyl)azetidine(1079366-88-3)
• EPA Substance Registry System: (R)-2-phenyl-1-(toluene-4-sulfonyl)azetidine(1079366-88-3)

Safety Data

• Hazardous Substances Data: 1079366-88-3(Hazardous Substances Data)

Upstream product

• 170564-98-4 (R)-3-amino-3-phenyl-1-propanol 
• 98-59-9 p-toluenesulfonyl chloride 
• 37088-67-8 methyl (3R)-3-amino-3-phenylpropanoate 
• 936012-06-5 C₁₆H₁₇NO₄S 
• 883458-37-5 (R)-(+)-methyl 3-(4-methylphenylsulfonamido)-3-phenylpropanoate 
• 158009-86-0 (S_S,3R)-(+)-methyl 3-[N-(p-toluenesulfinyl)amino]-3-(phenyl)propanoate 
• 153277-49-7 (S)-N-benzylidene-4-toluenesulfinamide 
• 875535-33-4 (3R)-3-phenyl-3-(4-toluenesulfonyl)aminopropionitrile 
• 875438-77-0 (2S)-O-(p-toluenesulfonyl)-N-(p-toluenesulfonyl)phenylglycinol 
• 20989-17-7 (2S)-2-phenylglycinol 
• 2935-35-5 (S)-2-phenylglycine 
• 1774-47-6 trimethylsulfoxonium iodide 
• 24395-14-0 (S)-N-(p-tolylsulfonyl)-2-phenylaziridine 

Downstream Products

• 824390-95-6 2-methyl-4-phenyl-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyrimidine 
• 1186384-41-7 (R)-N-(3-(3-bromopropoxy)-3-phenylpropyl)-4-methylbenzenesulfonamide 
• 1186384-40-6 (R)-N-(3-(2-bromoethoxy)-3-phenylpropyl)-4-methylbenzenesulfonamide 

Relevant articles and documents

Palladium-Catalyzed Regioselective and Stereospecific Ring-Opening Suzuki-Miyaura Arylative Cross-Coupling of 2-Arylazetidines with Arylboronic Acids

We have developed a palladium-catalyzed regioselective and enantiospecific ring-opening Suzuki–Miyaura arylative cross-coupling of N-tosyl-2-arylazetidines to give enantioenriched 3,3-diarylpropylamines. This reaction represents an example of transition-metal-catalyzed ring-opening cross-coupling using azetidines as a non-classical alkyl electrophile. Density functional theory rationalized the mechanism of the full catalytic cycle, which consists of the selectivity-determining ring opening of the azetidine, reaction with water, rate-determining transmetalation, and reductive elimination. Transition states of the selectivity-determining ring-opening step were systematically determined by the multi-component artificial force induced reaction (MC-AFIR) method to explain the regioselectivity of the reaction. (Figure presented.).

Metal-free one-pot synthesis of 2-substituted and 2,3-disubstituted morpholines from aziridines

The metal-free synthesis of 2-substituted and 2,3-disubstituted morpholines through a one-pot strategy is described. A simple and inexpensive ammonium persulfate salt enables the reaction of aziridines with halogenated alcohols to proceed via an SN2-type ring opening followed by cyclization of the resulting haloalkoxy amine.