108097-23-0

Basic information

• Product Name: 6-imino-2-thioxo-5-{[3,4,5-tris(methyloxy)phenyl]methyl}-2,5-dihydro-4(3H)-pyrimidinone
• CAS NO: 108097-23-0
• Molecular Weight: 323.373
• Mol File: 108097-23-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-imino-2-thioxo-5-{[3,4,5-tris(methyloxy)phenyl]methyl}-2,5-dihydro-4(3H)-pyrimidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-imino-2-thioxo-5-{[3,4,5-tris(methyloxy)phenyl]methyl}-2,5-dihydro-4(3H)-pyrimidinone(108097-23-0)
• EPA Substance Registry System: 6-imino-2-thioxo-5-{[3,4,5-tris(methyloxy)phenyl]methyl}-2,5-dihydro-4(3H)-pyrimidinone(108097-23-0)

Safety Data

• Hazardous Substances Data: 108097-23-0(Hazardous Substances Data)

Upstream product

• 29958-02-9 2-cyano-3-(3,4,5-trimethoxy-phenyl)propionic acid ethyl ester 
• 17356-08-0 thiourea 

Relevant articles and documents

6-Imino-2-thioxo-pyrimidinones as a new class of dipeptidyl peptidase IV inhibitors

Dipeptidyl peptidase IV is a glycoprotein which removes N-terminal dipeptides from physiologically relevant polypeptides. An homologous series of 6-imino-2-thioxo-5-{[3,4,5-tris(methyloxy)phenyl]methyl}-2,5-dihydro-4(3H) -pyrimidinones has been tested for inhibition of DPP IV activity. The inhibitory effects at 0.1 mM were observed. Enzyme kinetic studies revealed that compounds inhibit DPP IV activity competitively. According to the molecular docking analysis, the inhibitors are anchored into the DPP IV hydrolytic site by interactions of the pyrimidinone core with Glu206, Tyr662, and Tyr547, with the alkyl chain entering the S1 pocket. We conclude that pyrimidinone-like compounds are a promising new scaffold for reversible inhibition of DPP IV. Springer Science+Business Media, LLC 2011.