29958-02-9Relevant articles and documents
The Knoevenagel condensation using quinine as an organocatalyst under solvent-free conditions
Jain, Kavita,Chaudhuri, Saikat,Pal, Kuntal,Das, Kalpataru
, p. 1299 - 1304 (2019)
The Knoevenagel condensation between active methylene compounds and aromatic carobonyl compounds has been developed using quinine as an organocatalyst to afford various electrophilic alkenes in excellent yields (up to 90%). In the presence of a catalytic amount of quinine (15 mol%), the reaction proceeded at room temperature (RT) under solvent-free conditions. In this green approach, the organocatalyst was recovered and recycled for up to four cycles without appreciable loss of activity.
A systematic study on Knoevenagel reaction and Nazarov cyclization of less reactive carbonyl compounds using rare earth triflates and its applications
Ilangovan,Muralidharan,Maruthamuthu
experimental part, p. 1000 - 1006 (2012/02/05)
A systematic study of Knoevenagel reaction and Nazarov cyclization was made on variety of less reactive carbonyl compounds such as β-ketoesters, 1,3-diketones and cyclic active methylene compounds using Yb(OTf)3 as the catalyst. Recycling study confirms reusability of the catalyst without much loss of activity.
Unprecedented reaction between ethyl α-cyanocinnamate and o-phenylenediamine: Development of an efficient method for the transfer hydrogenation of electronically depleted olefins
Kumar, Satish,Kapoor, Kamal K.
, p. 2809 - 2814 (2008/02/13)
A reaction between ethyl α-cyanocinnamate and o-phenylenediamine under thermal conditions yielded 2-cyano-3-phenyl-propionic acid ethyl ester, 2-phenyl benzimidazole, and ethyl cyanoacetate. The mechanistic revelations led to the development of a simple and efficient transfer-hydrogenation process from the in situ generated benzimidazolines to activated olefins under solventless and catalyst-free conditions. Georg Thieme Verlag Stuttgart.
