108138-17-6

Basic information

• Product Name: 3-Quinolinecarboxylic acid, 1-(2,4-difluorophenyl)-6,7-difluoro-1,4-dihydro-4-oxo-, ethyl ester
• CAS NO: 108138-17-6
• Molecular Formula: C18H11F4NO3
• Molecular Weight: 365.284
• Mol File: 108138-17-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-Quinolinecarboxylic acid, 1-(2,4-difluorophenyl)-6,7-difluoro-1,4-dihydro-4-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarboxylic acid, 1-(2,4-difluorophenyl)-6,7-difluoro-1,4-dihydro-4-oxo-, ethyl ester(108138-17-6)
• EPA Substance Registry System: 3-Quinolinecarboxylic acid, 1-(2,4-difluorophenyl)-6,7-difluoro-1,4-dihydro-4-oxo-, ethyl ester(108138-17-6)

Safety Data

• Hazardous Substances Data: 108138-17-6(Hazardous Substances Data)

Upstream product

• 129322-83-4 2',4',5'-trifluoroacetophenone 
• 141451-70-9 ethyl 2-(2-chloro-4,5-difluorobenzoyl)-3-(2,4-difluorophenylamino) acrylate 
• 88419-56-1 2,4,5-trifluorobenzoyl chloride 
• 367-23-7 1,2,4-trifluorobenzene 
• 98349-24-7 ethyl 2,4,5-trifluorobenzoylacetate 
• 367-25-9 2,4-difluorophenylamine 
• 108115-67-9 ethyl 3-(2,4-difluoroanilino)-2-(2,4,5-trifluorobenzoyl)acrylate 

Downstream Products

• 145122-70-9 ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-(6,9-diazaspiro<4,5>decan-9-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 114677-01-9 (2'S,4'S)-7-(4'-acetamido-2'-methylpyrrolidinyl)-1-(2,4-difluorophenyl)-1,4-dihydro-6-fluoro-4-oxoquinoline-3-carboxylic acid ethyl ester 
• 114677-03-1 7-((2R,4S)-4-Acetylamino-2-hydroxymethyl-pyrrolidin-1-yl)-1-(2,4-difluoro-phenyl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 103995-01-3 6,7-difluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid 
• 143656-55-7 1-(2,4-difluorophenyl)-7-(1,4-dioxa-2-methyl-7-azaspiro[4.4]non-7-yl)-6-fluoro-1.4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester 
• 130982-86-4 (R)-(+)-temafloxacin 
• 130982-85-3 (S)-(-)-temafloxacin 
• 122928-98-7 7-<3-(methoxyimino)pyrrolidinyl>-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 
• 139524-70-2 7-<4-(methoxyimino)piperidinyl>-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 
• 139524-66-6 7-(3-oxopyrrolidinyl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 
• 139524-81-5 7-(4-oxopiperidinyl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 
• 114676-51-6 (2'R,4'S)-7-<4'-amino-2'-(hydroxymethyl)pyrrolidinyl>-1-(2,4-difluorophenyl)-1,4-dihydro-6-fluoro-4-oxoquinoline-3-carboxylic acid 
• 114676-80-1 (2'S,4'S)-7-<4'-amino-2'-(hydroxymethyl)pyrrolidinyl>-1-(2,4-difluorophenyl)-1,4-dihydro-6-fluoro-4-oxoquinoline-3-carboxylic acid 
• 114718-07-9 (1'S,4'S)-7-(2',5'-diazabicyclo<2.2.1>heptan-2'-yl)-1-(2,4-difluorophenyl)-1,4-dihydro-6-fluoro-4-oxoquinoline-3-carboxylic acid hydrochloride 

Relevant articles and documents

PROCESSES FOR PREPARING QUINOLONECARBOXYLATE DERIVATIVES

The present invention provides a process for preparing quinolonecarboxylate derivatives under a mild condition in high yield, so as to be favorably applied to a large-scale mass production thereof.

Synthesis, Antibacterial Activities, and Pharmacological Properties of Enantiomers of Temafloxacin Hydrochloride

Temafloxacin hydrochloride is a potent member of the 4-pyridone-3-carboxylic acid class of antibacterial agents and is currently under clinical development as a broad-spectrum antimicrobial agent.It is a racemate having a chiral center at the C3 of the 7-piperazin-1-yl group.The two enantiomers were synthesized and tested for their antibacterial activities.Although no difference in in vitro antibacterial activities was observed, a minor difference in in vivo antibacterial activities was observed.However, they both exhibited similar pharmacological profiles.