108294-56-0

Basic information

• Product Name: 2-({2,6-dichloro-4-[3,3-(1,4-butanediyl)triazeno]phenyl}imino)imidazolidine
• Synonyms: 2-({2,6-dichloro-4-[3,3-(1,4-butanediyl)triazeno]phenyl}imino)imidazolidine
• CAS NO: 108294-56-0
• Molecular Weight: 327.216
• Mol File: 108294-56-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-({2,6-dichloro-4-[3,3-(1,4-butanediyl)triazeno]phenyl}imino)imidazolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-({2,6-dichloro-4-[3,3-(1,4-butanediyl)triazeno]phenyl}imino)imidazolidine(108294-56-0)
• EPA Substance Registry System: 2-({2,6-dichloro-4-[3,3-(1,4-butanediyl)triazeno]phenyl}imino)imidazolidine(108294-56-0)

Safety Data

• Hazardous Substances Data: 108294-56-0(Hazardous Substances Data)

Upstream product

• 65936-26-7 2-(2',6'-dichloro-4'-nitroanilino)-2-imidazoline 
• 73218-65-2 (2,6-dichloro-4-nitrophenyl)carbonimidic dichloride 
• 123-75-1 pyrrolidine 
• 66711-21-5 p-aminoclonidine 

Downstream Products

• 108294-58-2 [125I]-p-Iodoclonidine 

Relevant articles and documents

Radioiodinated p-iodoclonidine: a high-affinity probe for the alpha 2-adrenergic receptor.

The chemical synthesis of 2-[(2,6-dichloro-4-iodophenyl)imino]imidazolidine (PIC) and its radioiodinated analogue [125I]PIC is described. PIC was synthesized from 2,6-dichloroaniline in five synthetic steps. This agent displayed a high affinity for the alpha 2-adrenergic receptor (IC50 = 1.5 nM) in competitive binding assays conducted with purified human platelet plasma membrane fractions. For the synthesis of radioiodinated PIC the triazene intermediate 11 was synthesized from 2,6-dichloro-4-nitroaniline in five synthetic steps. Acid-catalyzed decomposition of 11 with no-carrier-added Na125I afforded high specific activity [125I]PIC. In view of its high affinity for the alpha 2-adrenergic receptor, [125I]PIC is a potentially useful probe for studies in adrenergic pharmacology.