65936-26-7

Basic information

• Product Name: N-(2,6-Dichloro-4-nitrophenyl)-4,5-dihydro-1H-imidazole-2-amine
• Synonyms: 2-(2,6-Dichloro-4-nitrophenylimino)imidazolidine;N-(2,6-Dichloro-4-nitrophenyl)-4,5-dihydro-1H-imidazole-2-amine
• CAS NO: 65936-26-7
• Molecular Formula: C₉H₈Cl₂N₄O₂
• Molecular Weight: 275.09
• Mol File: 65936-26-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2,6-Dichloro-4-nitrophenyl)-4,5-dihydro-1H-imidazole-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,6-Dichloro-4-nitrophenyl)-4,5-dihydro-1H-imidazole-2-amine(65936-26-7)
• EPA Substance Registry System: N-(2,6-Dichloro-4-nitrophenyl)-4,5-dihydro-1H-imidazole-2-amine(65936-26-7)

Safety Data

• Hazardous Substances Data: 65936-26-7(Hazardous Substances Data)

Upstream product

• 73218-65-2 (2,6-dichloro-4-nitrophenyl)carbonimidic dichloride 
• 107-15-3 ethylenediamine 
• 70106-94-4 N-(2,6-dichloro-4-nitrophenyl)formamide 
• 99-30-9 4-nitro-2,6-dichloroaniline 

Downstream Products

• 66711-21-5 p-aminoclonidine 
• 108294-56-0 2-({2,6-dichloro-4-[3,3-(1,4-butanediyl)triazeno]phenyl}imino)imidazolidine 
• 66711-21-5 para-aminoclonidine 

Relevant articles and documents

A α2 - Adrenergic receptor agonist hydrochloric acid an le decides and its preparation method

The invention relates to an alpha2-adrenergic receptor stimulant apraclonidine hydrochloride and a preparation method thereof. The structural formula is shown in the specification. The preparation comprises the following steps: 2, 6-dichloro-4-nitroaniline, formic acid and acetic anhydride are mixed, heated and stirred, react and recrystallize, N-(2, 6-dichloro-4-nitrophenyl) formamide is obtained and then stirred, flows back and reacts with sulfuryl chloride and thionyl chloride, N-(2, 6-dichloro-4-nitrophenyl) dichlorocarbamide is obtained and dropwise added to an ethyl acetate solution containing ethylenediamine and triethylamine, the mixture is stirred for reaction for 1-10 h under the condition of 5-8 DEG C, 2-(2',6'-dichloro-4'- nitroanilino)-2-imidazoline is prepared, then a reducing agent is added to the solvent for reduction, hydrochloric acid is finally added to a reaction liquid, and stirring and backflow are performed for 1.5 h for preparation. The preparation process is simple to operate, the yield is high, the cost is low, the reaction route is short, little three wastes are generated, and industrial production is facilitated.

Process for preparation of clonidine derivatives

A novel process for preparing clonidine derivatives has been discovered which is shorter, less expensive and safer than previously known methods. A new thiourea complex has also been discovered which can be directly cyclized to produce the corresponding heterocyclic product.