108446-80-6

Basic information

• Product Name: 3-(4-BROMOPHENYL)-1-PHENYLPYRAZOLE-4-PROPIONIC ACID
• Synonyms: 3-(4-BROMOPHENYL)-1-PHENYLPYRAZOLE-4-PROPIONIC ACID;3-(3-(4-BROMOPHENYL)-1-PHENYL-1H-PYRAZOL-4-YL)PROPANOIC ACID
• CAS NO: 108446-80-6
• Molecular Formula: C₁₈H₁₅BrN₂O₂
• Molecular Weight: 371.23
• Product Categories: Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrazoles;PyrazolesHeterocyclic Building Blocks
• Mol File: 108446-80-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 156-161 °C
• Boiling Point: 548.4±45.0 °C(Predicted)
• Appearance: /
• Density: 1.43±0.1 g/cm3(Predicted)
• PKA: 4.44±0.10(Predicted)
• CAS DataBase Reference: 3-(4-BROMOPHENYL)-1-PHENYLPYRAZOLE-4-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-BROMOPHENYL)-1-PHENYLPYRAZOLE-4-PROPIONIC ACID(108446-80-6)
• EPA Substance Registry System: 3-(4-BROMOPHENYL)-1-PHENYLPYRAZOLE-4-PROPIONIC ACID(108446-80-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 108446-80-6(Hazardous Substances Data)

Usage

Family

Pyrazole derivatives

Chemical structure

contains a pyrazole ring with a bromophenyl and phenyl group attached to it

Properties

potential pharmaceutical and medicinal properties, exhibits anti-inflammatory and analgesic activities

Potential uses

being studied for treatment of pain and inflammatory conditions
Promising candidate for further research and development in drug discovery and medicinal chemistry

Upstream product

• 108446-73-7 (E)-3-[3-(4-Bromo-phenyl)-1-phenyl-1H-pyrazol-4-yl]-acrylic acid 
• 2033-24-1 cycl-isopropylidene malonate 
• 36640-41-2 3-(4-bromophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde 
• 108446-68-0 2-[3-(4-Bromo-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid 
• 108446-86-2 2-[3-(4-Bromo-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid diethyl ester 
• 10591-75-0 4-bromoacetophenone phenylhydrazone 

Relevant articles and documents

A simple and rapid synthesis of 4H-4-oxo-1-benzopyran-3-yl and 1,3-diarylpyrazol-4-yl propanoic acids

A simple and rapid synthesis of 4H-4-oxo-1-benzopyran-3-yl (4a-h) and 1,3-diarylpyrazol-4-yl propanoic acids (5a-h) using Meldrum's acid (1) from the corresponding carboxaldehydes (2 & 3) is reported herein.