108446-86-2

Basic information

• Product Name: 2-[3-(4-Bromo-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid diethyl ester
• Synonyms: 2-[3-(4-Bromo-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid diethyl ester
• CAS NO: 108446-86-2
• Molecular Weight: 469.335
• Mol File: 108446-86-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[3-(4-Bromo-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[3-(4-Bromo-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid diethyl ester(108446-86-2)
• EPA Substance Registry System: 2-[3-(4-Bromo-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid diethyl ester(108446-86-2)

Safety Data

• Hazardous Substances Data: 108446-86-2(Hazardous Substances Data)

Upstream product

• 10591-75-0 4-bromoacetophenone phenylhydrazone 
• 105-53-3 diethyl malonate 
• 36640-41-2 3-(4-bromophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde 

Downstream Products

• 108446-80-6 3-(4-bromophenyl)-1-phenylpyrazole-4-propionic acid 
• 108446-73-7 (E)-3-[3-(4-Bromo-phenyl)-1-phenyl-1H-pyrazol-4-yl]-acrylic acid 
• 108446-68-0 2-[3-(4-Bromo-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid 

Relevant articles and documents

Azoles. 17. Beta-(4-pyrazol)acrylic and propionic acids and their anti-inflammatory activity

beta-(4-Pyrazole)acrylic acids 22-28 were prepared by the Knoevenagel reaction of malonic acid and 4-formylpyrazoles 8-14. 4-Pyrazolemethylenemalonic acids 15-21 were isolated as intermediates. The latter compounds were also synthesized by treating the 4-formylpyrazoles 8-14 with diethyl malonate followed by hydrolysis of the obtained diethyl esters 15a-21a. The effect of piperidine and pyridine on the Knoevenagel condensation was investigated. The beta-(4-pyrazole)acrylic acids 22-27, on catalytic reduction, gave the corresponding beta-(4-pyrazole)propionic acids 29-34. Compounds 23, 24, 27, 29-31 and 34 appeared to be less active than phenylbutazone in carrageenin-induced oedema test, but they were less toxic than the reference drug.