108552-98-3

Basic information

• Product Name: 1H-Indazol-3-amine, 1-(2-phenylethyl)-
• CAS NO: 108552-98-3
• Molecular Formula: C15H15N3
• Molecular Weight: 237.304
• Mol File: 108552-98-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Indazol-3-amine, 1-(2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indazol-3-amine, 1-(2-phenylethyl)-(108552-98-3)
• EPA Substance Registry System: 1H-Indazol-3-amine, 1-(2-phenylethyl)-(108552-98-3)

Safety Data

• Hazardous Substances Data: 108552-98-3(Hazardous Substances Data)

Upstream product

• 132475-60-6 2-bromobenzamidoxime 
• 2042-37-7 o-cyanobromobenzene 
• 113385-42-5 2-(1-Phenethyl-1H-indazol-3-yl)-isoindole-1,3-dione 
• 874-05-5 3-aminoindazole 
• 103-63-9 1-phenyl-2-bromoethane 
• 82575-23-3 2-(1H-indazol-3-yl)isoindoline-1,3-dione 

Relevant articles and documents

Cascade Synthesis of Kinase-Privileged 3-Aminoindazoles via Intramolecular N-N Bond Formation

3-Aminoindazoles are privileged scaffolds for bioactive drug-like molecules. In this study, a microwave-assisted cascade reaction for the synthesis of N-1 substituted 3-aminoindazoles with yields up to 81% has been developed. Starting from 3-(2-bromoaryl)-1,2,4-oxadiazol-5(4H)-ones, the reaction exhibits a broad substrate scope including anilines, aliphatic amines, and sulfonamides and bypasses selectivity issues between N-1 and 3-amino group. Furthermore, the Differential Scanning Fluorimetry screen of a kinase panel demonstrated the value of targeting N-1 substituted 3-aminoindazoles as kinase-biased fragments.