82575-23-3

Basic information

• Product Name: 2-(1H-Indazol-3-yl)-1H-isoindole-1,3(2H)-dione
• Synonyms: 2-(1H-Indazol-3-yl)-1H-isoindole-1,3(2H)-dione;3-Phthalimid-1-yl-1H-indazole;3-Phthalimidoindazole;2-(1H-indazol-3-yl)isoindole-1,3-dione
• CAS NO: 82575-23-3
• Molecular Formula: C₁₅H₉N₃O₂
• Molecular Weight: 263.25086
• Mol File: 82575-23-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 239-240°C
• Appearance: /
• CAS DataBase Reference: 2-(1H-Indazol-3-yl)-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1H-Indazol-3-yl)-1H-isoindole-1,3(2H)-dione(82575-23-3)
• EPA Substance Registry System: 2-(1H-Indazol-3-yl)-1H-isoindole-1,3(2H)-dione(82575-23-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 82575-23-3(Hazardous Substances Data)

Usage

Chemical classification

Indazole derivative

Usage

Commonly used in pharmaceutical and chemical research

Biological activities

Anti-inflammatory, anticancer, and antimicrobial properties

Potential

Promising candidate for the development of new drugs and therapeutic agents

Research status

Further research needed to fully understand its potential applications and mechanisms of action in medicinal chemistry.

Upstream product

• 85-44-9 phthalic anhydride 
• 874-05-5 3-aminoindazole 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 394-47-8 2-fluorobenzonitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 88-67-5 2-Iodobenzoic acid 

Downstream Products

• 113385-42-5 2-(1-Phenethyl-1H-indazol-3-yl)-isoindole-1,3-dione 
• 108552-99-4 1-propyl-1H-indazol-3-amine 
• 108552-98-3 1-Phenethyl-1H-indazol-3-ylamine 
• 60301-20-4 3-amino-1-methyl-1H-indazole 
• 69835-35-4 3-diethylamino-propyl bromide hydrobromide 

Relevant articles and documents

“On water” nano-Cu2O-catalyzed CO-free one-pot multicomponent cascade cyanation-annulation-aminolysis reaction toward phthalimides

An efficient nano-Cu2O-catalyzed cascade multicomponent reaction of 2-halobenzoic acids and trimethylsilyl cyanide with diverse amines was developed using water as a solvent, affording versatileN-substituted phthalimide derivatives in moderate to excellent yields. This novel strategy features carbon monoxide gas-free, environmentally benign, one-pot multistep transformation, commercially available reagents, a cheap catalyst without any additives, wide functional group tolerance, and operational convenience.

Studies on 3-aminoindazoles. I. Synthesis of 1- or 3-(substituted 3-amino)indazoles

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3-Aminoindazole derivatives

A compound of the formula (I): STR1 wherein W1 is a hydrogen atom or a STR2 group wherein Y is a C1-6 alkylene group or a C1-6 alkylene group having a C1-6 alkyl group substituent; and R1 and R2 each independently is a hydrogen atom or a C1-6 alkyl group and R1 and R2 may form a C4-6 heterocyclic ring or a nitrogen-containing C4-6 heterocyclic ring together with the adjacent nitrogen atom and the C4-6 heterocyclic rings may have at least one C1-6 alkyl group, hydroxyl group or halogen atom; W2 is a hydrogen atom or a STR3 group wherein Z is a C1-6 alkylene group or a C1-6 alkylene group having a C1-6 alkyl group substituent; and R3 and R4 each independently is a hydrogen atom or a C1-6 alkyl group and R3 and R4 may form a C4-6 heterocyclic ring or a nitrogen-containing C4-6 heterocyclic ring together with the adjacent nitrogen atom and the C4-6 heterocyclic rings may have at least one C1-6 alkyl group, hydroxyl group or halogen atom; when W1 is a hydrogen atom, W2 is the STR4 group; and when W2 is a hydrogen atom, W1 is the STR5 group; and the pharmaceutically acceptable acid addition salt thereof having antiinflammatory, analgesic and digestive tract ulcer suppressing activity.