1085526-67-5

Basic information

• Product Name: (4-tert-butylphenyl)ethynyl bromide
• Synonyms: (4-tert-butylphenyl)ethynyl bromide
• CAS NO: 1085526-67-5
• Molecular Weight: 237.139
• Mol File: 1085526-67-5.mol
• Article Data: 28

Chemical Properties

• CAS DataBase Reference: (4-tert-butylphenyl)ethynyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: (4-tert-butylphenyl)ethynyl bromide(1085526-67-5)
• EPA Substance Registry System: (4-tert-butylphenyl)ethynyl bromide(1085526-67-5)

Safety Data

• Hazardous Substances Data: 1085526-67-5(Hazardous Substances Data)

Upstream product

• 772-38-3 4-tert-Butylphenylacetylene 
• 939-97-9 4-tert-Butylbenzaldehyde 
• 220006-53-1 3-(4-(tert-butyl)phenyl)propiolic acid 

Downstream Products

• 1085526-68-6 3-[(4-tert-butylphenyl)ethynyl]-1,3-oxazolidin-2-one 
• 1085526-72-2 3,3'-(2-(4-tert-butylphenyl)ethene-1,1-diyl)dioxazolidin-2-one 
• 183210-84-6 1,4-bis(4-tert-butylphenyl)buta-1,3-diyne 
• 30095-47-7 2-bromo-1-(4-(tert-butyl)phenyl)ethanone 
• 1638667-34-1 (Z)-5-(2-bromo-3-(4-(tert-butyl)phenyl)-3-chloroallyl)dihydrofuran-2(3H)-one 
• 1638667-23-8 (Z)-4-(2-bromo-3-(4-(tert-butyl)phenyl)-3-chloroallyl)oxetan-2-one 
• 1316104-46-7 1-tert-butyl-4-[4-(4-methoxyphenyl)buta-1,3-diyn-1-yl]benzene 
• 1345719-54-1 diethyl [(4-tert-butylphenyl)ethynyl]phosphonate 
• 1415029-92-3 1-(tert-butyl)-4-(pent-4-en-1-yn-1-yl)benzene 

Relevant articles and documents

Modular synthesis of heptaarylindole

The first synthesis of heptaarylindole (HAI) has been accomplished using a coupling/ring transformation strategy. Four readily prepared modular units (diarylthiophenes, 2-arylaziridines, arylboronic acids, and arylalkynes) were joined together to provide

Visible Light-Induced Difunctionalization of Alkynes: The Synthesis of Thiazoles and 1,1-Dibromo-1-en-3-ynes

A visible light-induced cascade cyclization of thioamides with alkynes was developed to synthesize 1,3-thiozoles. The sulfur radical generated from thioamide via the single-electron transfer (SET) pathway was promoted by photocatalysis as a key intermediate in this reaction. When bromoalkynes were used as the substrate, the self-coupling products 1,1-dibromo-1-en-3-ynes were obtained in moderate yields, and an energy transfer pathway for this transformation promoted by visible-light photocatalysis was proposed.

A Radical-Initiated Fragmentary Rearrangement Cascade of Ene-Ynamides to [1,2]-Annulated Indoles via Site-Selective Cyclization

Straightforward access to [1,2]-annulated indoles, key substructures in natural products, is highly desirable yet challenging. Herein, a radical triggered fragmentary cyclization cascade reaction of ene-ynamides is presented, providing a rapid access into [1,2]-annulated indoles by an intermolecular radical addition, intramolecular cyclization, desulfonylative aryl migration, and site-selective C(sp2)-N cyclization sequence. DFT calculations support oxidation of N-centered radical species to cations prior to the C-N bond formation, followed by an unusual aza-Nazarov cyclization.

A Micellar Catalysis Strategy for Amidation of Alkynyl Bromides: Synthesis of Ynamides in Water

Copper-catalyzed amidation of alkynyl bromides can be carried out in water for the first time, which is made possible by a micellar catalysis strategy using rosin-based surfactant APGS-550-M. The surfactant can be easily prepared from natural abundant biomass, resin acids. Studies as to substrate scope and reaction aqueous medium recycling showcase the ease and sustainability of this technology.