30095-47-7

Basic information

• Product Name: 2-BROMO-1-(4-TERT-BUTYL-PHENYL)-ETHANONE
• Synonyms: 2-Bromo-4'-tert-butylacetophenone;2-BroMo-1-[4-(1,1-diMethylethyl)phenyl]ethanone;4-(2-BroMoacetyl)-tert-butylbenzene;p-tert-Butyl α-broMoacetophenone;p-tert-Butyl-ω-broMoacetophenone
• CAS NO: 30095-47-7
• Molecular Formula: C₁₂H₁₅BrO
• Molecular Weight: 255.16
• Product Categories: Aromatics
• Mol File: 30095-47-7.mol
• Article Data: 46

Chemical Properties

• Boiling Point: 305.8°Cat760mmHg
• Flash Point: 36.7°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 0.000805mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 2-BROMO-1-(4-TERT-BUTYL-PHENYL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-(4-TERT-BUTYL-PHENYL)-ETHANONE(30095-47-7)
• EPA Substance Registry System: 2-BROMO-1-(4-TERT-BUTYL-PHENYL)-ETHANONE(30095-47-7)

Safety Data

• Hazardous Substances Data: 30095-47-7(Hazardous Substances Data)

Usage

General Description

2-BROMO-1-(4-TERT-BUTYL-PHENYL)-ETHANONE, also known as 4-tert-Butylphenacylbromide, is a chemical compound with the molecular formula C12H15BrO. It is an organic compound and a derivative of acetophenone, with a bromine atom attached to the alpha carbon. 2-BROMO-1-(4-TERT-BUTYL-PHENYL)-ETHANONE is commonly used in organic synthesis as a reagent for the synthesis of various pharmaceuticals and organic compounds. It is utilized in the production of various drugs such as anti-inflammatory and analgesic medications. Additionally, it is used as an intermediate in the synthesis of other organic compounds and is widely employed in research and development processes in the pharmaceutical and chemical industries.

InChI:InChI=1/C12H15BrO/c1-12(2,3)10-6-4-9(5-7-10)11(14)8-13/h4-7H,8H2,1-3H3

Upstream product

• 943-27-1 4'-t-butylacetophenone 
• 1746-23-2 4-tert-Butylstyrene 
• 1159013-48-5 2-bromo-1-(4-(tert-butyl)phenyl)ethan-1-ol 
• 7364-19-4 4-ethyl-tert-butylbenzene 
• 1710-98-1 p-tert-butyl benzoyl chloride 
• 1085526-67-5 (4-tert-butylphenyl)ethynyl bromide 
• 772-38-3 4-tert-Butylphenylacetylene 
• 101325-12-6 1-(4-tert-butylphenyl)ethanol 
• 939-97-9 4-tert-Butylbenzaldehyde 
• 936078-06-7 2,2‐dibromo‐1‐(4‐tert‐butylphenyl)ethan‐1‐one 
• 22118-09-8 2-bromoacetyl chloride 
• 253185-03-4 tert-butylbenzene 
• 186581-53-3 diazomethane 
• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 

Downstream Products

• 6321-03-5 1-(4-tert-butyl-phenacyl)-6-chloro-quinolinium; bromide 
• 6321-04-6 1-(4-tert-butyl-phenacyl)-1-methyl-1,2,3,4-tetrahydro-quinolinium; bromide 
• 180901-27-3 2-(4'-t-butylphenyl)-6-chloroimidazo<1,2-b>pyridazine 
• 81539-65-3 4-(4-tert-Butyl-phenyl)-N¹-[1-phenyl-meth-(Z)-ylidene]-imidazole-1,2-diamine 
• 156897-26-6 6-(4-tert-Butyl-phenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine 
• 161139-73-7 1-(4-tert-Butyl-phenyl)-2-(3,5-dimethoxy-phenylamino)-ethanone 
• 3488-46-8 1-[4-(tert-butyl)phenyl]-2-diazoethanone 
• 180900-93-0 2-(4-tert-Butyl-phenyl)-6-phenylsulfanyl-imidazo[1,2-b]pyridazine 
• 180901-18-2 2-(4-tert-Butyl-phenyl)-6-phenoxy-imidazo[1,2-b]pyridazine 
• 156146-58-6 2-(4-tert-Butyl-phenyl)-6-fluoro-imidazo[1,2-b]pyridazine 
• 188692-68-4 2-(4-tert-Butyl-phenyl)-6-iodo-imidazo[1,2-a]pyridine 
• 188692-49-1 2-(4-tert-Butyl-phenyl)-6-iodo-imidazo[1,2-b]pyridazine 
• 183667-89-2 6-(4-tert-Butyl-phenyl)-imidazo[2,1-b]thiazole 

Relevant articles and documents

PREPARATION OF PYRAZOLO[3,4-B]PYRIDINES AS ANTIMALARIALS

The present invention relates to pyrazolo[3,4-b]pyridine compounds. The present invention further relates to methods for inhibiting Plasmodium comprising contacting Plasmodium with pyrazolo[3,4-b]pyridine compounds described herein. Also described herein are methods of treating malaria comprising administering pyrazolo[3,4-b]pyridine compounds to a subject in need thereof.

Selective Debromination of α,α,α-Tribromomethylketones with HBr–H2O Reductive Catalytic System

A debromination of α,α,α-tribromomethylketones is developed for chemoselective synthesis of α-mono- and α,α-dibromomethylketones with high selectivity under H2O–HBr reductive conditions. This method offers an efficient and direct way to synthesize α-mono or α,α-dibromomethylketone compounds in high to excellent yields through the process of HBr self-circulation in water.

Synthesis and Structure-Activity Relationship of Dual-Stage Antimalarial Pyrazolo[3,4- b]pyridines

Malaria remains one of the most deadly infectious diseases, causing hundreds of thousands of deaths each year, primarily in young children and pregnant mothers. Here, we report the discovery and derivatization of a series of pyrazolo[3,4-b]pyridines targeting Plasmodium falciparum, the deadliest species of the malaria parasite. Hit compounds in this series display sub-micromolar in vitro activity against the intraerythrocytic stage of the parasite as well as little to no toxicity against the human fibroblast BJ and liver HepG2 cell lines. In addition, our hit compounds show good activity against the liver stage of the parasite but little activity against the gametocyte stage. Parasitological profiles, including rate of killing, docking, and molecular dynamics studies, suggest that our compounds may target the Qo binding site of cytochrome bc1.