180901-18-2

Basic information

• Product Name: 2-(4-tert-Butyl-phenyl)-6-phenoxy-imidazo[1,2-b]pyridazine
• Synonyms: 2-(4-tert-Butyl-phenyl)-6-phenoxy-imidazo[1,2-b]pyridazine
• CAS NO: 180901-18-2
• Molecular Weight: 343.428
• Mol File: 180901-18-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-tert-Butyl-phenyl)-6-phenoxy-imidazo[1,2-b]pyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-tert-Butyl-phenyl)-6-phenoxy-imidazo[1,2-b]pyridazine(180901-18-2)
• EPA Substance Registry System: 2-(4-tert-Butyl-phenyl)-6-phenoxy-imidazo[1,2-b]pyridazine(180901-18-2)

Safety Data

• Hazardous Substances Data: 180901-18-2(Hazardous Substances Data)

Upstream product

• 30095-47-7 2-bromo-1-(4-(tert-butyl)phenyl)ethanone 
• 39539-69-0 6-phenoxypyridazin-3-amine 

Relevant articles and documents

Imidazo[1,2-b]pyridazines. XX syntheses of some 3-acylaminomethyl-6-(chloro, fluoro, methoxy, methylthio, phenoxy and phenylthio)-2-(phenyl, 4-t-butylphenyl, 4-cyclohexylphenyl, β-naphthyl and styryl)imidazo[1,2-b]pyridazines and their interaction with central and peripheral-type benzodiazepine receptors

Some 3-(aliphatic and aromatic)acylaminomethyl derivatives of 6-(chloro, fluoro, methoxy, methylthio, phenoxy and phenylthio)-2-(phenyl, 4-t-butylphenyl, 4-cyclohexylphenyl, β-naphthyl and styryl)imidazo[1,2-b]pyridazines have been prepared and tested for binding to central benzodiazepine receptors present in rat brain membrane, and to peripheral-type (mitochondrial) benzodiazepine receptors present in rat kidney membrane. Some of these compounds which contained 2-(4-t-butylphenyl, 4-cyclohexylphenyl and styryl) substituents bound strongly and selectively to peripheral-type benzodiazepine receptors. For example, 2-(4′-t-butylphenyl)-6-chloro-2-(4″-fluorobenzamidomethyl)imidazo[1, 2-b]pyridazine in tests for the displacement of [3H]diazepam from both peripheral-type and central benzodiazepine receptors gave IC50 1.0 nM and 9% displacement at 1000 nM, respectively. Steric effects appeared to be more restrictive in the interaction of these ligands with central benzodiazepine receptors rather than with peripheral-type benzodiazepine receptors; X-ray structure analyses of two typical compounds are reported.