1710-98-1Relevant articles and documents
Design, synthesis, biological evaluation and molecular modeling studies of novel eugenol esters as leishmanicidal agents
Coelho, Camila M.,Dos Santos, Thiago,Freitas, Poliany G.,Nunes, Juliana B.,Marques, Marcos J.,Padovani, Camila G. D.,Júdice, Wagner A. S.,Camps, Ihosvany,Da Silveira, Nelson J. F.,Carvalho, Diogo T.,Veloso, Marcia P.
, p. 715 - 728 (2018)
Leishmaniasis is a neglected pathology with a high incidence worldwide, and is a governmental health issue due to the increased morbidity and mortality associated with the disease and a scarce therapeutic arsenal. Cysteine proteases have been investigated
Facile synthesis of polyamide dendrimers from unprotected AB2 building blocks: Dumbbell-shaped dendrimer, star-shaped dendrimer, and dendrimer with a carboxylic acid at the core
Washio, Isao,Shibasaki, Yuji,Ueda, Mitsuru
, p. 2237 - 2246 (2005)
A fast, inexpensive, and highly efficient synthesis of aromatic polyamide dendrimers, without the need for protection and deprotection steps, has been developed. Dendrons and various types of polyamide dendrimers were easily prepared by a convergent appro
Synthesis and Characterization of Copper Complexes with the N-(2,6-Diisopropylphenyl)-N′-acylthiourea Ligands
Wang, Dan,Wu, Su-Yun,Li, Hai-Pu,Yang, Ying,Roesky, Herbert W.
, p. 1406 - 1413 (2017)
Three N-(2,6-diisopropylphenyl)-N′-acylthiourea ligands [Ar′NHC(S)NHC(O)Ar; Ar′ = 2,6-iPr2C6H3; Ar = p-tBuC6H4 (1, L1), Mes (2, L2), and 1-Naph (3, L3)] were synthesized and compared with the homologous ligand L0 (Ar = Ph) in terms of their resultant complexes with copper halides. The reaction of L1 with CuCl2 led to the formation of mononuclear L12CuCl (4), while treatment of L1 with CuX (X = Cl, Br) resulted in the adamantane cage complexes (L1CuX)4 (X = Cl, 5; Br, 6). These findings are similar to the results shown by its parent ligand L0. The reaction of L1 with CuI yielded the iodide-bridged dimeric complex [L12Cu(μ-I)]2 (7), in contrast to the ligand-bridged dimer supported by L0. L2 readily afforded the mononuclear CuI complexes 8–10 coordinated by two or three ligands. L3 gave monomeric L33CuX (X = Cl, 11; Br, 12) and the iodide-bridged dimeric [L32Cu(μ-I)]2 (13). L3 can bind with CuI halides in a ratio of 1:1 to give complexes L3CuX(PPh3)2 (14–16), when Cu2X2(PPh3)3 (X = Cl, Br) or CuI(PPh3)3 were used as precursors. Treatment of (L1CuCl)4 (5), L22CuBr (8), and L33CuCl (11), respectively, with hot EtOH resulted in the formation of trans-CuLn′2 (17–19) compounds. All compounds were characterized by single-crystal X-ray diffraction studies.
One-step Conversion of Amides and Esters to Acid Chlorides with PCl3
Li, Fangshao,Wu, Xiaofang,Guo, Fengzhe,Tang, Zi-Long,Xiao, Jing
supporting information, p. 4314 - 4317 (2021/07/16)
A general and efficient iodine-promoted chlorination of amides and esters with phosphorus trichloride is described. For the first time. Various inactivated amides including secondary and tertiary amides were directly converted to the corresponding acid chlorides in one-step. The substrate scope of methyl esters including aromatic and aliphatic esters was also explored under this system. This method is simple, scalable and wide in scope, which provides an approach to preparation of these acid chlorides.
Electrochemical intramolecular C-H/N-H functionalization for the synthesis of isoxazolidine-fused isoquinolin-1(2: H)-ones
Zhang, Lin-Bao,Geng, Rui-Sen,Wang, Zi-Chen,Ren, Guang-Yi,Wen, Li-Rong,Li, Ming
supporting information, p. 16 - 21 (2020/01/13)
A general and practical protocol for the construction of isoxazolidine-fused isoquinolin-1(2H)-ones has been described by electrochemical-oxidation-induced intramolecular annulation via amidyl radicals. In an undivided cell, isoquinolinones could be easily generated from various available amides bearing CONHOR groups under metal-free, additive-free and external oxidant-free conditions. Moreover, this transformation proceeded smoothly by using cheap 95% ethanol as the green solvent and could be extended to the gram scale.
