110244-54-7Relevant articles and documents
Palladium Catalyzed Cascade Azidation/Carbonylation of Aryl Halides with Sodium Azide for the Synthesis of Amides
Qi, Zhuang,Li, Shan-Shan,Li, Lin,Qin, Qi,Yang, Li-Miao,Liang, Ying-Kang,Kang, Yun,Zhang, Xiang-Zhi,Ma, Ai-Jun,Peng, Jin-Bao
, p. 503 - 506 (2021)
Amide synthesis is one of the most important transformations in organic chemistry due to their ubiquitous presence in our daily life. In this communication, a palladium catalyzed cascade azidation/carbonylation of aryl halides for the synthesis of amides was developed. Both iodo- and bromobenzene derivatives were transformed to the corresponding amides using PdCl2/xantphos as the catalyst system and sodium azide as the nitrogen-source. The reaction proceeds via a cascade azidation/carbonylation process. A range of alkyl and halogen substituted amides were prepared in moderate to good yields.
Mild environment-friendly oxidative debenzylation of N-benzylanilines using DMSO as an oxidant
Yoshinaga, Tatsuro,Iwata, Takayuki,Shindo, Mitsuru
supporting information, p. 191 - 194 (2020/02/25)
Oxidative debenzylation of N-benzyl aromatic amines using DMSO as a non-toxic oxidant and catalyzed by TsOH gave Nphenylimines, which were spontaneously hydrolyzed to form anilines and benzaldehydes in good yields. This reaction employs mild, metal-free conditions. The conditions are also suitable for the debenzylation of benzylphenylethers.
Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein
White, Kris M.,Abreu, Pablo,Wang, Hui,De Jesus, Paul D.,Manicassamy, Balaji,García-Sastre, Adolfo,Chanda, Sumit K.,Devita, Robert J.,Shaw, Megan L.
, p. 146 - 157 (2018/02/14)
S119 was a top hit from an ultrahigh throughput screen performed to identify novel inhibitors of influenza virus replication. It showed a potent antiviral effect (50% inhibitory concentration, IC50 = 20 nM) and no detectable cytotoxicity (50% c
