1085541-60-1

Basic information

• Product Name: N-chloroacetyl-(1R)-phenyl-1,2,3,4-tetrahydroisoquinoline
• Synonyms: N-chloroacetyl-(1R)-phenyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 1085541-60-1
• Molecular Weight: 285.773
• Mol File: 1085541-60-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-chloroacetyl-(1R)-phenyl-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: N-chloroacetyl-(1R)-phenyl-1,2,3,4-tetrahydroisoquinoline(1085541-60-1)
• EPA Substance Registry System: N-chloroacetyl-(1R)-phenyl-1,2,3,4-tetrahydroisoquinoline(1085541-60-1)

Safety Data

• Hazardous Substances Data: 1085541-60-1(Hazardous Substances Data)

Upstream product

• 79-04-9 chloroacetyl chloride 
• 180272-45-1 (R)-(-)-1-phenyl-1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 180272-45-1 (R)-(-)-1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 242478-37-1 solifenacin 
• 881834-78-2 4-nitrophenyl-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 22990-19-8 1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 22990-19-8 (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 180468-42-2 (S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

PROCESSES FOR THE PREPARATION OF SOLIFENACIN OR A SALT THEREOF

The present invention describes recovery and racemization of (1R)-Phenyl- 1,2,3,4-tetrahydroisoquinoline of compound of formula (III) to obtain racemic 1- phenyl-1, 2,3,4-tetrahydroisoquinoline of compound of formula (I) and its further resolution to get ( IS)-1-phenyl-1, 2, 3, 4-tetrahydroisoquinoline (intermediate B) in high chemical and chiral purity, which is the key intermediate for the preparation of (3R)-azabicyclo[2.2.2]oct-3-yl (1S)-1-phenyl-3,4-dihydroisoquinoline-2-(1H)- carboxylate.