881834-78-2

Basic information

• Product Name: 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-1-phenyl-, 4-nitrophenyl ester
• CAS NO: 881834-78-2
• Molecular Formula: C22H18N2O4
• Molecular Weight: 374.396
• Mol File: 881834-78-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-1-phenyl-, 4-nitrophenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-1-phenyl-, 4-nitrophenyl ester(881834-78-2)
• EPA Substance Registry System: 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-1-phenyl-, 4-nitrophenyl ester(881834-78-2)

Safety Data

• Hazardous Substances Data: 881834-78-2(Hazardous Substances Data)

Upstream product

• 1085541-60-1 N-chloroacetyl-(1R)-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 22990-19-8 1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 7693-46-1 4-Nitrophenyl chloroformate 
• 180272-45-1 (R)-(-)-1-phenyl-1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 22990-19-8 (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 180272-45-1 (R)-(-)-1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 242478-37-1 solifenacin 
• 22990-19-8 1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 180468-42-2 (S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 1300713-32-9 N-acetyl-(1R)-phenyl-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

PROCESSES FOR THE PREPARATION OF SOLIFENACIN OR A SALT THEREOF

The present invention describes recovery and racemization of (1R)-Phenyl- 1,2,3,4-tetrahydroisoquinoline of compound of formula (III) to obtain racemic 1- phenyl-1, 2,3,4-tetrahydroisoquinoline of compound of formula (I) and its further resolution to get ( IS)-1-phenyl-1, 2, 3, 4-tetrahydroisoquinoline (intermediate B) in high chemical and chiral purity, which is the key intermediate for the preparation of (3R)-azabicyclo[2.2.2]oct-3-yl (1S)-1-phenyl-3,4-dihydroisoquinoline-2-(1H)- carboxylate.