1300713-32-9

Basic information

• Product Name: N-acetyl-(1R)-phenyl-1,2,3,4-tetrahydroisoquinoline
• Synonyms: N-acetyl-(1R)-phenyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 1300713-32-9
• Molecular Weight: 251.328
• Mol File: 1300713-32-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-acetyl-(1R)-phenyl-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: N-acetyl-(1R)-phenyl-1,2,3,4-tetrahydroisoquinoline(1300713-32-9)
• EPA Substance Registry System: N-acetyl-(1R)-phenyl-1,2,3,4-tetrahydroisoquinoline(1300713-32-9)

Safety Data

• Hazardous Substances Data: 1300713-32-9(Hazardous Substances Data)

Upstream product

• 75-36-5 acetyl chloride 
• 180272-45-1 (R)-(-)-1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 881834-78-2 4-nitrophenyl-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 52250-50-7 1-phenyl-3,4-dihydroisoquinoline 
• 108-24-7 acetic anhydride 

Downstream Products

• 242478-37-1 solifenacin 
• 22990-19-8 1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 22990-19-8 (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 180468-42-2 (S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Enantioselective synthesis of 1-aryl-tetrahydroisoquinolines through iridium catalyzed asymmetric hydrogenation

Asymmetric hydrogenation of 1-aryl-3,4-dihydroisoquinolines using the [IrCODCl]2/(R)-3,5-diMe-Synphos catalyst is reported. Under mild reaction conditions, this atom-economical process provides easy access to a variety of enantioenriched 1-aryl-1,2,3,4-tetrahydroisoquinoline derivatives, which are important pharmacophores found in several pharmaceutical drug candidates, in high yields and enantiomeric excesses up to 99% after a single crystallization.