1086026-31-4Relevant articles and documents
AN IMPROVED PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
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Page/Page column 20; 21; 22, (2019/11/12)
: Disclosed herein is an improved process for the preparation of Ivabradine and pharmaceutically acceptable salts thereof. The invention more particularly disclosesthe synthesis of key intermediates viz.,(S)-N-[(4,5-dimethoxybenzocydobut-l-yl)-methyl]-N- (methyl)amine hydrochloride of Formula-II and 3-(3-Iodopropyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzapin-2-one of Formula-III, and its use in industrial synthesis of Ivabradine and pharmaceutically acceptable salts thereof.
Dehydrogenated ivabradine synthesizing method
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Paragraph 0035; 0036; 0037; 0038; 0040; 0043; 0046; 0049, (2018/04/02)
The invention relates to the technical field of organic chemical synthesis, in particular to a dehydrogenated ivabradine synthesizing method and aims to solve technical problems of high impurity content and complexity in subsequent treatment in a dehydrogenated ivabradine synthesis process. The technical scheme for implementation includes that a synthetic route includes: adding a compound (III) orsalts thereof and a compound (II) into a nonpolar solvent, mixing, adding inorganic base, iodine compounds and a phase transfer catalyst, and heating for stirring reaction to obtain a compound (I). The dehydrogenated ivabradine synthesizing method has advantages that impurity (A) content can be evidently reduced, reaction liquid purity can be remarkably improved while product yield is increased,an aftertreatment process is simplified, complicated operations of distillation or repeated extraction in use of polar solvents are avoided, and the method is more suitable for industrialization.
PROCESS FOR THE PREPARATION OF BENZAZEPINE-2-ONE DERIVATIVE
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, (2017/09/05)
The present, invention relates to a cost effective, environment friendly industrially viable process for the preparation of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepine-2-one, an intermediate used in the preparation of ivabradine, without using acid chloride intermediate and condensing agent.