1220993-48-5

Basic information

• Product Name: (R)-4,5-dimethoxy-1,2-dihydrocyclobutabenzene-1-carboxylic acid
• Synonyms: (R)-4,5-dimethoxy-1,2-dihydrocyclobutabenzene-1-carboxylic acid
• CAS NO: 1220993-48-5
• Molecular Weight: 208.214
• Mol File: 1220993-48-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-4,5-dimethoxy-1,2-dihydrocyclobutabenzene-1-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4,5-dimethoxy-1,2-dihydrocyclobutabenzene-1-carboxylic acid(1220993-48-5)
• EPA Substance Registry System: (R)-4,5-dimethoxy-1,2-dihydrocyclobutabenzene-1-carboxylic acid(1220993-48-5)

Safety Data

• Hazardous Substances Data: 1220993-48-5(Hazardous Substances Data)

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 41234-23-5 (R,S)-4,5-dimethoxy-1,2-dihydrocyclobutabenzene-1-carboxylic acid 

Downstream Products

• 1220993-43-0 (7S)-3,4-dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide 
• 1086026-31-4 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-(methyl)amino]propyl}-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 
• 41234-23-5 (R,S)-4,5-dimethoxy-1,2-dihydrocyclobutabenzene-1-carboxylic acid 
• 148849-67-6 ivabradine hydrochloride 
• 866783-13-3 1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride 

Relevant articles and documents

Method for synthesizing (1S)-4,5-dimethoxy-1-(carbonylaminomethyl)benzocyclobutane

The invention relates to a method for synthesizing (1S)-4,5-dimethoxy-1-(carbonylaminomethyl)benzocyclobutane. The method provided by the invention does not need complicated high-cost column chromatographic methods for product purification or other special equipment, is good in operability, mild and safe in process, simple in reaction operation and beneficial for industrial production; and halogenated hydrocarbons are used as a solvent and are easy to recover and to use indiscriminately, and S-1-phenylethylamine is used as a resolving agent and is low in price and easy to recover, so production cost is greatly reduced. According to the invention, the synthesis is performed in organic acid, so racemization pollution is low, and environmentally friendliness is achieved; and the produced (1S)-4,5-dimethoxy-1-(carbonylaminomethyl)benzocyclobutane has few impurities and high chiral purity, wherein yield can reach 80-90% and HPLC purity is no less than 99%, so product quality is good.