108623-11-6

Basic information

• Product Name: N-Aethyl-N-(2-phenylcarbamoylaminoaethyl)-m-toluidin
• CAS NO: 108623-11-6
• Molecular Weight: 297.4
• Mol File: 108623-11-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-Aethyl-N-(2-phenylcarbamoylaminoaethyl)-m-toluidin(CAS DataBase Reference)
• NIST Chemistry Reference: N-Aethyl-N-(2-phenylcarbamoylaminoaethyl)-m-toluidin(108623-11-6)
• EPA Substance Registry System: N-Aethyl-N-(2-phenylcarbamoylaminoaethyl)-m-toluidin(108623-11-6)

Safety Data

• Hazardous Substances Data: 108623-11-6(Hazardous Substances Data)

Upstream product

• 102-27-2 N-ethyl-m-toulidine 
• 19248-13-6 N₁-ethyl-N₁-(3-methylphenyl)-1,2-ethanediamine 
• 103-71-9 phenyl isocyanate 

Relevant articles and documents

Discovery of small molecule antagonists of TRPV1

Small molecule antagonists of the vanilloid receptor 1 (TRPV1, also known as VR1) are disclosed. Ureas such as 5 (SB-452533) were used to explore the structure activity relationship with several potent analogues identified. Pharmacological studies using electrophysiological and FLIPR Ca2+ based assays showed compound 5 was an antagonist versus capsaicin, noxious heat and acid mediated activation of TRPV1. Study of a quaternary salt of 5 supports a mode of action in which compounds from this series cause inhibition via an extracellularly accessible binding site on the TRPV1 receptor.