19248-13-6

Basic information

• Product Name: N-(2-AMINOETHYL)-N-ETHYL-M-TOLUIDINE
• Synonyms: N-(2-AMINOETHYL)-N-ETHYL-M-TOLUIDINE;N-ethyl-N-(m-tolyl)ethylenediamine;N-Aminoethyl-N-ethyl-m-toluidine;NSC 151043;N-(2-Aminoethyl)-N-ethyl-3-methylbenzenamine;N-Ethyl-N-(3-methylphenyl)-1,2-ethanediamine;N-Ethyl-N-(β-aminoethyl)-m-toluidine;1,2-Ethanediamine, N-ethyl-N-(3-methylphenyl)-
• CAS NO: 19248-13-6
• Molecular Formula: C₁₁H₁₈N₂
• Molecular Weight: 178.27
• EINECS: 242-914-4
• Mol File: 19248-13-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 120 °C / 25mmHg
• Flash Point: 118.7°C
• Appearance: /
• Density: 0.98
• Vapor Pressure: 0.00177mmHg at 25°C
• Refractive Index: 1.5550-1.5580
• PKA: 9.44±0.10(Predicted)
• CAS DataBase Reference: N-(2-AMINOETHYL)-N-ETHYL-M-TOLUIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-AMINOETHYL)-N-ETHYL-M-TOLUIDINE(19248-13-6)
• EPA Substance Registry System: N-(2-AMINOETHYL)-N-ETHYL-M-TOLUIDINE(19248-13-6)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 19248-13-6(Hazardous Substances Data)

Usage

General Description

N-(2-aminoethyl)-N-ethyl-m-toluidine is a chemical compound with the molecular formula C11H18N2. It is a colorless to pale yellow liquid with a faint odor. N-(2-AMINOETHYL)-N-ETHYL-M-TOLUIDINE is commonly used in the production of dyes and pigments, as well as in the manufacturing of pharmaceuticals and in research laboratories. N-(2-aminoethyl)-N-ethyl-m-toluidine is also known to be a potential human carcinogen, with exposure to high levels of the compound being linked to an increased risk of cancer. As a result, proper handling and safety measures should be taken when working with this chemical.

InChI:InChI=1/C11H18N2/c1-3-13(8-7-12)11-6-4-5-10(2)9-11/h4-6,9H,3,7-8,12H2,1-2H3

Upstream product

• 151-56-4 ethyleneimine 
• 102-27-2 N-ethyl-m-toulidine 
• 2498-02-4 N-[2-(N-ethyl-m-toluidino)-ethyl]-phthalimide 
• 42816-34-2 N-Ethyl-N-(2-propionamidoethyl)-m-toluidine 
• 58861-74-8 2-bromoethylamine hydrochloride 
• 91-88-3 N-ethyl-N-(2-hydroxyethyl)-3-methylaniline 
• 22564-43-8 N-(2-chloro-ethyl)-N-ethyl-3-methyl-aniline 

Downstream Products

• 37717-68-3 N-[2-(N-ethyl-m-toluidino)-ethyl]-methanesulfonamide 
• 14118-02-6 N.N'Bis-<2-(N-aethyl-m-toluidino-aethyl)-dithiooxamid 
• 459429-39-1 SB 452533 
• 108623-11-6 N-Aethyl-N-(2-phenylcarbamoylaminoaethyl)-m-toluidin 
• 229627-08-1 3-[[2-(ethyl-m-tolyl-amino)-ethyl]-({2-[3-methoxy-4-(3-o-tolylureido)phenyl]-acetylamino}-acetyl)-amino]-propionic acid 
• 868593-15-1 N-{2-[ethyl(3-methylphenyl)amino]ethyl}-N'-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)urea 

Relevant articles and documents

Discovery of small molecule antagonists of TRPV1

Small molecule antagonists of the vanilloid receptor 1 (TRPV1, also known as VR1) are disclosed. Ureas such as 5 (SB-452533) were used to explore the structure activity relationship with several potent analogues identified. Pharmacological studies using electrophysiological and FLIPR Ca2+ based assays showed compound 5 was an antagonist versus capsaicin, noxious heat and acid mediated activation of TRPV1. Study of a quaternary salt of 5 supports a mode of action in which compounds from this series cause inhibition via an extracellularly accessible binding site on the TRPV1 receptor.

Nucleophilic Ring Opening of 2-Oxazolines with Amines: A Convenient Synthesis for Unsymmetrically Substituted Ethylenediamines

The reaction of 2-alkyl-2-oxazolines with alkyl- and arylamines was investigated.The acid-catalyzed nucleophilic ring opening of the 2-oxazolines yields N-(2-aminoethyl)carboxamides in good to excellent yields with secondary amines and hindered primary amines.The N-(2-aminoethyl)carboxamides were hydrolyzed under acidic or basic conditions to selectively yield unsymmetrically substituted ethylenediamines.