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459429-39-1

459429-39-1

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459429-39-1 Usage

Uses

SB 452533 is a potent, selective and orally bioavailable TRPV1 antagonist.

Check Digit Verification of cas no

The CAS Registry Mumber 459429-39-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,9,4,2 and 9 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 459429-39:
(8*4)+(7*5)+(6*9)+(5*4)+(4*2)+(3*9)+(2*3)+(1*9)=191
191 % 10 = 1
So 459429-39-1 is a valid CAS Registry Number.

459429-39-1 Well-known Company Product Price

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  • Sigma

  • (SML0890)  SB 452533  ≥98% (HPLC)

  • 459429-39-1

  • SML0890-5MG

  • 858.78CNY

  • Detail

  • Sigma

  • (SML0890)  SB 452533  ≥98% (HPLC)

  • 459429-39-1

  • SML0890-25MG

  • 3,473.73CNY

  • Detail

459429-39-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2-Bromophenyl)-3-{2-[ethyl(3-methylphenyl)amino]ethyl}ure

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:459429-39-1 SDS

459429-39-1Downstream Products

459429-39-1Relevant articles and documents

Discovery of small molecule antagonists of TRPV1

Rami, Harshad K.,Thompson, Mervyn,Wyman, Paul,Jerman, Jeffrey C.,Egerton, Julie,Brough, Stephen,Stevens, Alexander J.,Randall, Andrew D.,Smart, Darren,Gunthorpe, Martin J.,Davis, John B.

, p. 3631 - 3634 (2007/10/03)

Small molecule antagonists of the vanilloid receptor 1 (TRPV1, also known as VR1) are disclosed. Ureas such as 5 (SB-452533) were used to explore the structure activity relationship with several potent analogues identified. Pharmacological studies using electrophysiological and FLIPR Ca2+ based assays showed compound 5 was an antagonist versus capsaicin, noxious heat and acid mediated activation of TRPV1. Study of a quaternary salt of 5 supports a mode of action in which compounds from this series cause inhibition via an extracellularly accessible binding site on the TRPV1 receptor.

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