108644-85-5

Basic information

• Product Name: (E)-(R)-1,1,1-trifluoro-4-phenyl-3-buten-2-ol
• Synonyms: (E)-(R)-1,1,1-trifluoro-4-phenyl-3-buten-2-ol
• CAS NO: 108644-85-5
• Molecular Weight: 202.176
• Mol File: 108644-85-5.mol
• Article Data: 39

Chemical Properties

• CAS DataBase Reference: (E)-(R)-1,1,1-trifluoro-4-phenyl-3-buten-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-(R)-1,1,1-trifluoro-4-phenyl-3-buten-2-ol(108644-85-5)
• EPA Substance Registry System: (E)-(R)-1,1,1-trifluoro-4-phenyl-3-buten-2-ol(108644-85-5)

Safety Data

• Hazardous Substances Data: 108644-85-5(Hazardous Substances Data)

Upstream product

• 89524-12-9 1-phenyl-3-hydroxy-4,4,4-trifluoro-1-butyne 
• 122920-70-1 (E)-1,1,1-trifluoro-4-phenylbut-3-en-2-yl acetate 
• 14371-10-9 (E)-3-phenylpropenal 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 104-55-2 3-phenyl-propenal 
• 97-72-3 2-Methylpropionic anhydride 
• 80768-54-3 (+/-)-E-1,1,1-trifluoro-4-phenylbut-3-en-2-ol 
• 536-74-3 phenylacetylene 
• 100-42-5 styrene 
• 3108-32-5 (E)-1,1,1-trifluoro-4-phenyl-3-buten-2-one 
• 340-07-8 N-(trifluoroacetyl)piperidine 
• 100-52-7 benzaldehyde 
• 212378-97-7 (R(S))-N-(1-phenylethylidene)-tert-butanesulfinamide 
• 431-35-6 3-bromo-1,1,1-trifluoroacetone 

Downstream Products

• 111004-15-0 (E)-(S)-1,1,1-trifluoro-4-phenyl-3-buten-2-ol 
• 1135311-99-7 (E)-(S)-1,1,1-trifluoro-4-phenyl-3-buten-2-yl isobutyrate 
• 1135312-35-4 (E)-1,1,1-trifluoro-4-phenyl-3-buten-2-yl isobutyrate 
• 122920-70-1 (E)-1,1,1-trifluoro-4-phenylbut-3-en-2-yl acetate 
• 130980-00-6 (E)-3,4-cyclopropyl-1,1,1-trifluoro-4-phenyl-2-butanone 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AS ANTI-VIRAL AGENTS

The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV) or HMPV. The present invention further relates to pharmaceutical compositions comp

Enantioselective Palladium-Catalyzed [3+2] Cycloaddition of Trimethylenemethane and Fluorinated Ketones

A nitrile-substituted trimethylenemethane (TMM) donor undergoes palladium-catalyzed [3+2] cycloadditions with fluorinated ketones to generate tetrasubstituted trifluoromethylated centers in high enantioselectivity under mild conditions. The generation of the palladium–TMM complex was achieved by a self-deprotonation strategy, which shows remarkable improvements in regiocontrol, efficiency, and atom economy of asymmetric [3+2] cycloadditions. Moreover, the versatility of the nitrile group provides direct access to a variety of synthetically useful intermediates, including amides, aldehydes, and esters. The developed reaction conditions allow for the synthesis of a wide variety of aromatic, heteroaromatic, and aliphatic fluorinated dihydrofurans in excellent regio- and enantioselectivities.

Development of (Trifluoromethyl)zinc Reagent as Trifluoromethyl Anion and Difluorocarbene Sources

The trifluoromethylation of carbonyl compounds is accomplished by the stable (trifluoromethyl)zinc reagent generated and then isolated from CF3I and ZnEt2, which can be utilized as a trifluoromethyl anion source (CF3-). The reaction proceeds smoothly with diamine as a ligand and ammonium salt as an initiator, providing the corresponding trifluoromethylated alcohol products. Moreover, the (trifluoromethyl)zinc reagent can also be employed as a difluorocarbene source (:CF2) not only for gem-difluoroolefination of carbonyl compounds with phosphine but also for gem-difluorocyclization of alkenes or alkynes via the thermal decomposition, respectively.