108787-34-4

Basic information

• Product Name: bis(N,N-diisopropylamino)-2-(4-nitrophenyl)ethoxyphosphane
• Synonyms: bis(N,N-diisopropylamino)-2-(4-nitrophenyl)ethoxyphosphane
• CAS NO: 108787-34-4
• Molecular Weight: 397.498
• Mol File: 108787-34-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: bis(N,N-diisopropylamino)-2-(4-nitrophenyl)ethoxyphosphane(CAS DataBase Reference)
• NIST Chemistry Reference: bis(N,N-diisopropylamino)-2-(4-nitrophenyl)ethoxyphosphane(108787-34-4)
• EPA Substance Registry System: bis(N,N-diisopropylamino)-2-(4-nitrophenyl)ethoxyphosphane(108787-34-4)

Safety Data

• Hazardous Substances Data: 108787-34-4(Hazardous Substances Data)

Upstream product

• 100-27-6 2-(4-nitrophenyl)ethanol 
• 108-18-9 diisopropylamine 
• 20264-95-3 2-(4-nitrophenyl)ethyl chloride 
• 56183-63-2 bis(diisopropylamino)chlorophosphine 

Downstream Products

• 1207997-71-4 2'-deoxy-N⁴,5'-O-bis{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine 3'-[2-(4-nitrophenyl)ethyl N,N-diisopropylphosphoramidite] 
• 1263363-72-9 3-[(2,4-dinitrophenyl)amino]propyl 2-(4-nitrophenyl)ethyl N,N-diisopropylphosphoramidite 
• 1263363-73-0 4-[(2,4-dinitrophenyl)amino]butyl 2-(4-nitrophenyl)ethyl N,N-diisopropylphosphoramidite 
• 1414882-33-9 5'-O-dimethoxytrityl-3'-O-[2-(4-nitrophenyl)ethoxy-N,N-diisopropyl]-2'-deoxyribofuranosyl-3-guanyl-N,N-bis[2-(4-nitrophenyl)ethoxycarbonyl]urea phosphoramidite 
• 136340-66-4 C₇₀H₆₅N₈O₁₆PS 
• 195881-29-9 5'-O-[(2-cyano-1-phenylethoxy)carbonyl]-N²-{[2-(4-nitrophenyl)ethoxy]carbonyl}-O⁶-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine 3'-2-(4-nitrophenyl)ethyl diisopropylphosphoramidite 
• 195881-28-8 5'-O-[(2-cyano-1-phenylethoxy)carbonyl]-N⁶-{[2-(4-nitrophenyl)ethoxy]carbonyl}-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)adenosine 3'-2-(4-nitrophenyl)ethyl diisopropylphosphoramidite 
• 195881-48-2 5'-O-[(2-cyano-1-phenylethoxy)carbonyl]-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)cytidine 3'-2-(4-nitrophenyl)ethyl diisopropylphosphoramidite 
• 195881-45-9 5'-O-[(2-cyano-1-phenylethoxy)carbonyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)uridine 3'-2-(4-nitrophenyl)ethyl diisopropylphosphoramidite 
• 179397-58-1 Acetic acid 2-{(2R,3R,4R,5R)-2-{diisopropylamino-[2-(4-nitro-phenyl)-ethoxy]-phosphanyloxymethyl}-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxysulfonyloxy]-tetrahydro-furan-3-yloxy}-ethyl ester 
• 168772-63-2 3'-deoxy-N⁶,5'-O-bis-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl N,N-diisopropylphosphoramidite> 

Relevant articles and documents

2',5'-phosphorothioate/phosphodiester oligoadenylates and anti-viral uses thereof

Optically active antiviral compounds having the formula STR1 wherein m is 0, 1, 2, or 3; n and q are selected from the group of 0 and 1, provided that n and q may not both be zero; and R, R1, and R2 are independently of each other selected from the group consisting of oxygen and sulfur, provided that all R, R1 and R2, may not be oxygen, and further provided that all R, R1, and R2 may not be sulfur. The compounds possess increased antiviral activity and/or metabolic stability.

Use of NPE-protecting groups for the preparation of oligonucleotides without using nucleophiles during the final deprotection

The preparation of O-(4-nitrophenyl)ethyl phosphoramidites and H- phosphonate derivatives of Npe protected nucleosides is described together with the use of these products to prepare oligodeoxynucleotides without using nucleophiles during the final deprot

New Approach to the Synthesis of Deoxyribonucleoside Phosphoramidite Derivatives

The deoxyribonucleoside phosphoramidites with various protecting groups at phosphorus have been prepared rapidly in good yields in one-pot reaction from bis(diisopropylamino)chlorophosphine as a new phosphitylating agent without isolation of bis(diisopropylamino)alkoxyphosphines.