108895-47-2

Basic information

• Product Name: Uridine, 2'-deoxy-5-ethyl-5'-O-(triphenylmethyl)-, 3'-methanesulfonate
• CAS NO: 108895-47-2
• Molecular Formula: C31H32N2O7S
• Molecular Weight: 576.67
• Mol File: 108895-47-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Uridine, 2'-deoxy-5-ethyl-5'-O-(triphenylmethyl)-, 3'-methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: Uridine, 2'-deoxy-5-ethyl-5'-O-(triphenylmethyl)-, 3'-methanesulfonate(108895-47-2)
• EPA Substance Registry System: Uridine, 2'-deoxy-5-ethyl-5'-O-(triphenylmethyl)-, 3'-methanesulfonate(108895-47-2)

Safety Data

• Hazardous Substances Data: 108895-47-2(Hazardous Substances Data)

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 67912-88-3 5'-O-Trityl-5-ethyl-2'-deoxyuridine 
• 76-83-5 trityl chloride 
• 15176-29-1 edoxudine 

Downstream Products

• 105380-85-6 1-(5-O-trityl-2-deoxy-β-D-threo-pentofuranosyl)-5-ethyluracil 
• 105380-81-2 5'-O-trityl-2,3'-anhydro-2'-deoxy-5-ethyluridine 
• 114008-11-6 5-ethyl-3'-iodo-5'-O-trityl-2',3'-dideoxyuridine 
• 108895-49-4 5-ethyl-2',3'-dideoxyuridine 
• 105380-82-3 3'-azido-5-ethyl-5'-O-trityl-2',3'-dideoxyuridine 

Relevant articles and documents

Antimycobacterial activities of 5-alkyl (or halo)-3′-substituted pyrimidine nucleoside analogs

Several 5-alkyl (or halo)-3′-azido (amino or halo) analogs of pyrimidine nucleosides have been synthesized and evaluated against Mycobacterium bovis, Mycobacterium tuberculosis and Mycobacterium avium. Among these compounds, 3′-azido-5-ethyl-2′,3′-dideoxyuridine (3) was found to have significant antimycobacterial activities against M. bovis (MIC 50 = 1 μg/mL), M. tuberculosis (MIC50 = 10 μg/mL) and M. avium (MIC50 = 10 μg/mL).

Structure-Activity Relationships of Pyrimidine Nucleosides as Antiviral Agents for Human Immunodeficiency Virus Type 1 in Peripheral Blood Mononuclear Cells

The structure-activity relationships of several pyrimidine nucleosides related to 3'-azido-3'-deoxythymidine (AZT) were determined in human immunodeficiency virus type 1 (HIV-1) infected human peripheral blood mononuclear cells.These studies indicated tha

3'-Substituted 2',3'-Dideoxynucleoside Analogues as Potential Anti-HIV (HTLV-III/LAV) Agents

A series of 2',3'-unsaturated and 3'-substituted 2',3'-dideoxynucleoside analogues of purines and pyrimidines have been synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV).The 2',3'-unsaturated analogues of 2',3'-dideoxycytidine (ddeCyd) and 2',3'-dideoxythymidine (ddeThd), 3'-azido-2',3'-dideoxythymidine (AzddThd), 3'-fluoro-2',3'-dideoxythymidine, 2',3'-dideoxycytidine (ddCyd), and 2',3'-dideoxyadenosine (ddAdo) emerged as the most potent inhibitors of HIV-induced cytopathogenicity in the human T lymphocyte cell lines ATH8 and MT4.In ATH8 cells ddCyd, ddeCyd, and ddAdo had the highest therapeutic index whereas in MT4 cells AzddThd, ddThd, ddCyd, and ddAdo were the most selective.Derivatives from ddThd in which the substituent group was linked to the 3'-carbon atom via a thio, sulfonyl, or oxygen bridge were far less inhibitory to HIV than was AzddThd.