114008-11-6

Basic information

• Product Name: Uridine, 2',3'-dideoxy-5-ethyl-3'-iodo-5'-O-(triphenylmethyl)-
• CAS NO: 114008-11-6
• Molecular Formula: C30H29IN2O4
• Molecular Weight: 608.476
• Mol File: 114008-11-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Uridine, 2',3'-dideoxy-5-ethyl-3'-iodo-5'-O-(triphenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Uridine, 2',3'-dideoxy-5-ethyl-3'-iodo-5'-O-(triphenylmethyl)-(114008-11-6)
• EPA Substance Registry System: Uridine, 2',3'-dideoxy-5-ethyl-3'-iodo-5'-O-(triphenylmethyl)-(114008-11-6)

Safety Data

• Hazardous Substances Data: 114008-11-6(Hazardous Substances Data)

Upstream product

• 76-83-5 trityl chloride 
• 7285-11-2 chloroform methanol 
• 108895-47-2 1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-ribopentafuranosyl)-5-ethyluracil 
• 15176-29-1 edoxudine 
• 67912-88-3 5'-O-Trityl-5-ethyl-2'-deoxyuridine 

Downstream Products

• 108895-49-4 5-ethyl-2',3'-dideoxyuridine 

Relevant articles and documents

Antimycobacterial activities of 5-alkyl (or halo)-3′-substituted pyrimidine nucleoside analogs

Several 5-alkyl (or halo)-3′-azido (amino or halo) analogs of pyrimidine nucleosides have been synthesized and evaluated against Mycobacterium bovis, Mycobacterium tuberculosis and Mycobacterium avium. Among these compounds, 3′-azido-5-ethyl-2′,3′-dideoxyuridine (3) was found to have significant antimycobacterial activities against M. bovis (MIC 50 = 1 μg/mL), M. tuberculosis (MIC50 = 10 μg/mL) and M. avium (MIC50 = 10 μg/mL).

Structure-Activity Relationships of Pyrimidine Nucleosides as Antiviral Agents for Human Immunodeficiency Virus Type 1 in Peripheral Blood Mononuclear Cells

The structure-activity relationships of several pyrimidine nucleosides related to 3'-azido-3'-deoxythymidine (AZT) were determined in human immunodeficiency virus type 1 (HIV-1) infected human peripheral blood mononuclear cells.These studies indicated tha