109-83-1 Usage
Description
2-Methylaminoethanol, also known as 2-(Methylamino)ethanol, is an ethanolamine compound with an N-methyl substituent. It is a clear, colorless, and viscous liquid that is less dense than water and soluble in water. The vapors of this compound are heavier than air and produce toxic oxides of nitrogen during combustion. It is used to make other chemicals and serves as an intermediate in various industries.
Uses
Used in Textile Chemicals:
2-Methylaminoethanol is used as a lubricant in the textile industry, providing smoothness and reducing friction during the manufacturing process. It enhances the quality and feel of the textiles, making them more comfortable and durable.
Used in Pharmaceuticals:
In the pharmaceutical industry, 2-Methylaminoethanol is used as an intermediate in the synthesis of various drugs. Its unique chemical properties make it a valuable component in the development of new medications.
Used in Personal Care Products:
2-Methylaminoethanol is utilized in the formulation of personal care products, such as cosmetics and skincare items. It helps improve the texture, consistency, and overall performance of these products, providing better results for the users.
Used in Detergents and Polishes:
2-Methylaminoethanol is used as an ingredient in detergents and polishes, enhancing their cleaning and polishing capabilities. It contributes to the effectiveness of these products, making them more efficient in removing dirt and stains.
Used in Electrostatic Automotive Coatings:
2-Methylaminoethanol is employed in the production of electrostatic automotive coatings, which provide a durable and long-lasting finish to vehicles. It improves the adhesion and coverage of the paint, ensuring a smooth and even application.
Used in Acid Gas Scrubbing:
In the field of environmental protection, 2-Methylaminoethanol is used in acid gas scrubbing processes. It helps in the removal of harmful acidic gases from industrial emissions, reducing the environmental impact of these pollutants.
Used in Polymers:
2-Methylaminoethanol serves as an intermediate in the production of various polymers. Its unique chemical properties make it an essential component in the synthesis of polymers with specific characteristics and applications.
Used in the Natural Gas-Processing Industry:
2-Methylaminoethanol is used as a solvent in the natural gas-processing industry. It aids in the separation and purification of natural gas, ensuring a cleaner and more efficient energy source.
Production Methods
Monomethylethanolamine is manufactured by reacting ethylene
oxide and methylamine with external cooling.
Air & Water Reactions
Soluble in water.
Reactivity Profile
2-Methylaminoethanol is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. 2-Methylaminoethanol may react with oxidizing materials.
Health Hazard
Exposure can cause irritation of eyes, nose and throat.
Safety Profile
Poison by
intraperitoneal route. Moderately toxic by
ingestion and subcutaneous routes. A
corrosive irritant to skin, eyes, and mucous
membranes. Flammable when exposed to
heat, flame, or oxidizers. To fight fire, use
alcohol foam. When heated to
decomposition it emits toxic fumes such as
NOx. See also AMINES and ALCOHOLS.
Check Digit Verification of cas no
The CAS Registry Mumber 109-83-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 9 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 109-83:
(5*1)+(4*0)+(3*9)+(2*8)+(1*3)=51
51 % 10 = 1
So 109-83-1 is a valid CAS Registry Number.
InChI:InChI=1/C3H9NO/c1-4-2-3-5/h4-5H,2-3H2,1H3/p+1
109-83-1Relevant articles and documents
Blount,Openshaw,Todd
, p. 286,289 (1940)
Easton,Dillard
, p. 1807,1809 (1963)
Schiff's Bases as Intermediates in the Hydrolytic Decomposition of 2-Alkyl-3-methyl-1,3-oxazolidines in Aqueous Acid
Pihlaja, Kalevi,Parkkinen, Aija,Loennberg, Harri
, p. 1223 - 1226 (1983)
The kinetics for the hydrolysis of 2-alkyl-3-methyl-1,3-oxazolidines have been examined spectrophotometrically in acidic solutions.The decomposition of the substrates to 2-methylaminoethanol and the corresponding aldehydes have been shown to proceed via stable intermediates which are kinetically and u.v.-spectroscopically very similar to the acyclic cationic Schiff's base derived from isobutyraldehyde and 2-methoxyethylmethylamine.The mechanisms for the formation and breakdown of the Schiff's base intermediate are discussed on the basis of pH-rate profiles, activation parameters, salt effects, and solvent deuterium isotope effects.
Electrochemical Reductive N-Methylation with CO2Enabled by a Molecular Catalyst
Rooney, Conor L.,Wu, Yueshen,Tao, Zixu,Wang, Hailiang
supporting information, p. 19983 - 19991 (2021/12/01)
The development of benign methylation reactions utilizing CO2 as a one-carbon building block would enable a more sustainable chemical industry. Electrochemical CO2 reduction has been extensively studied, but its application for reductive methylation reactions remains out of the scope of current electrocatalysis. Here, we report the first electrochemical reductive N-methylation reaction with CO2 and demonstrate its compatibility with amines, hydroxylamines, and hydrazine. Catalyzed by cobalt phthalocyanine molecules supported on carbon nanotubes, the N-methylation reaction proceeds in aqueous media via the chemical condensation of an electrophilic carbon intermediate, proposed to be adsorbed or near-electrode formaldehyde formed from the four-electron reduction of CO2, with nucleophilic nitrogenous reactants and subsequent reduction. By comparing various amines, we discover that the nucleophilicity of the amine reactant is a descriptor for the C-N coupling efficacy. We extend the scope of the reaction to be compatible with cheap and abundant nitro-compounds by developing a cascade reduction process in which CO2 and nitro-compounds are reduced concurrently to yield N-methylamines with high monomethylation selectivity via the overall transfer of 12 electrons and 12 protons.
Discovery of benzimidazole analogs as a novel interleukin-5 inhibitors
Boggu, Pulla Reddy,Kim, Youngsoo,Jung, Sang-Hun
, (2019/08/12)
A series of novel hydroxyethylaminomethylbenzimidazole analogs 5a-y were synthesized and evaluated for their IL-5 inhibitory activity using pro-B Y16 cell line. Among them, 2-(((4-(cyclohexylmethoxy)-1H-benzo[d]imidazol-2-yl)methyl)amino)butan-1-ol (5e, 94.3% inhibition at 30 μM, IC50 = 3.5 μM, cLogP = 4.132) and 3-cyclohexyl-2-(((4-(cyclohexylmethoxy)-1H-benzo[d]imidazol-2-yl)methyl)amino) propan-1-ol (5k, 94.7% inhibition at 30 μM, IC50 = 5.0 μM, cLogP = 6.253) showed the most potent inhibitory activity. The essential feature of SAR (Fig. 5) indicated that the chromenone ring can be replaced by a benzimidazole ring to maintain the inhibitory activity. In addition, the hydroxyethylaminomethyl group was suitable for the IL-5 inhibitory activity. Moreover, the hydrophobic substituents on carbon play an important role in the IL-5 inhibitory activity of these analogs. However, N-substituted analogs did not improve inhibitory activity. In addition, MTT assay of 5e and 5k with normal B lymphoblasts revealed that they had no significant effects on cell viability.