13200-60-7Relevant articles and documents
N, N -Bis-(dimethylfluorosilylmethyl)amides of N -organosulfonylproline and sarcosine: Synthesis, structure, stereodynamic behaviour and in silico studies
Nikolin, Alexey A.,Kramarova, Eugenia P.,Shipov, Alexander G.,Baukov, Yuri I.,Negrebetsky, Vadim V.,Arkhipov, Dmitry E.,Korlyukov, Alexander A.,Lagunin, Alexey A.,Bylikin, Sergey Yu.,Bassindale, Alan R.,Taylor, Peter G.
, p. 75315 - 75327 (2016)
(O→Si)-Chelate difluorides R3R2NCH(R1)C(O)N(CH2SiMe2F)2 (9a-c, R1R2 = (CH2)3, R3 = Ms (a), Ts (b); R1 = H, R2 = Me, R3 = Ms (c)), containing one penta- and one tetracoordinate silicon atoms were synthesized by silylmethylation of amides R3R2NCH(R1)C(O)NH2, subsequent hydrolysis of unstable intermediates R3R2NCH(R1)C(O)N(CH2SiMe2Cl)2 (7a-c) into 4-acyl-2,6-disilamorpholines R3R2NCH(R1)C(O)N(CH2SiMe2O)2 (8a-c) and the reaction of the latter compounds with BF3·Et2O. The structures of disilamorpholines 8a,c and difluoride 9a were confirmed by an X-ray diffraction study. According to the IR and NMR data, the O→Si coordination in solutions of these compounds was weaker than that in the solid state due to effective solvation of the Si-F bond. A permutational isomerisation involving an exchange of equatorial Me groups at the pentacoordinate Si atom in complexes 9a-c was detected, and its activational parameters were determined by 1H DNMR. In silico estimation of possible pharmacological effects and acute rat toxicity by PASS Online and GUSAR Online services showed a potential for their further pharmacological study.
An enzyme and its optional [...] modified ketone and inhibitor composition comprising (by machine translation)
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Paragraph 0392; 0393, (2017/01/23)
PROBLEM TO BE SOLVED: ketone-containing acrylic misuse, abuse or overload is prevented for a new takable amt. provitamin drag pain. SOLUTION: a compound represented by the following formula is represented, in which the drag oxystyrene provitamin hydrocodone ketone-containing acrylic. Pre-selected drug profile is modified and the ketone and schisandrin [...] holding hung contg. compsn. method for administration to a patient. Selected drawing: no (by machine translation)
Selective monomethylation of primary amines with simple electrophiles
Lebleu, Thomas,Ma, Xiaolu,Maddaluno, Jacques,Legros, Julien
supporting information, p. 1836 - 1838 (2014/02/14)
Direct monomethylation of primary amines with methyl triflate was achieved with high selectivity (up to 96%). The key point of this single methyl transfer stems from the use of HFIP as the solvent that interferes with amines and avoids overmethylation.
