13344-50-8

Basic information

• Product Name: N-nitrososarcosine ethyl ester
• Synonyms: N-nitrososarcosine ethyl ester;N-NITROSOSARCOSINEETHYL;N-Methyl-N-nitrosoglycine ethyl ester
• CAS NO: 13344-50-8
• Molecular Formula: C₅H₁₀N₂O₃
• Molecular Weight: 146.14
• Mol File: 13344-50-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 265.74°C (rough estimate)
• Flash Point: 107°C
• Appearance: /
• Density: 1.3394 (rough estimate)
• Vapor Pressure: 0.0184mmHg at 25°C
• Refractive Index: 1.4954 (estimate)
• CAS DataBase Reference: N-nitrososarcosine ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-nitrososarcosine ethyl ester(13344-50-8)
• EPA Substance Registry System: N-nitrososarcosine ethyl ester(13344-50-8)

Safety Data

• Hazardous Substances Data: 13344-50-8(Hazardous Substances Data)

Usage

Safety Profile

Moderately toxic by ingestion and intravenous routes. Many N-nitroso compounds are carcinogens. Questionable carcinogen with experimental carcinogenic and tumorigenic data. When heated to decomposition it emits toxic fumes of NOx.

InChI:InChI=1/C5H10N2O3/c1-3-10-5(8)4-7(2)6-9/h3-4H2,1-2H3

Upstream product

• 13200-60-7 Sarcosine ethyl ester 
• 52605-49-9 sarcosine ethyl ester hydrochloride 
• 80-11-5 N-methyl-N-nitrosotoluene-p-sulfonamide 

Relevant articles and documents

Reactivity of Nucleophilic Nitrogen Compounds towards the Nitroso Group

We discuss the reactivity of 43 nucleophilic nitrogen compounds towards the nitroso group of N-methyl-N-nitrosotoluene-p-sulfonamide (MNTS), and in some cases with alkyl nitrites.The series of nucleophiles considered is structurally very varied, includes members exhibiting the alpha effect, and covers 8 pKa units and a range of reactivities of almost five orders of magnitude.The values of solvent isotope effects and activation parameters have been measured and throw light on the structure of the transition states involved.Reactivities do not correlate well with thebasicity of the nucleophile, largely owing to the behaviour of primary amines, ammonia and nucleophiles with an alpha effect.Application of the curve crossing model suggests a relationship with vertical ionization potentials.The relationship with Ritchie's N+ scale is discussed, and interesting correlations with the reactivities of the same nucleophiles in various other chemical processes are noted.

Carcinogenic nitrosamines: Hundred-gram preparations of N-nitrosodiethylamine and α-ureidodimethylnitrosamine

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