1276121-84-6

Basic information

• Product Name: {[(S)-2-tert-butoxycarbonylamino-3-(2-nitrobenzenesulfonylamino)propionyl]methylamino}acetic acid ethyl ester
• Synonyms: {[(S)-2-tert-butoxycarbonylamino-3-(2-nitrobenzenesulfonylamino)propionyl]methylamino}acetic acid ethyl ester
• CAS NO: 1276121-84-6
• Molecular Weight: 488.519
• Mol File: 1276121-84-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: {[(S)-2-tert-butoxycarbonylamino-3-(2-nitrobenzenesulfonylamino)propionyl]methylamino}acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {[(S)-2-tert-butoxycarbonylamino-3-(2-nitrobenzenesulfonylamino)propionyl]methylamino}acetic acid ethyl ester(1276121-84-6)
• EPA Substance Registry System: {[(S)-2-tert-butoxycarbonylamino-3-(2-nitrobenzenesulfonylamino)propionyl]methylamino}acetic acid ethyl ester(1276121-84-6)

Safety Data

• Hazardous Substances Data: 1276121-84-6(Hazardous Substances Data)

Upstream product

• 13200-60-7 Sarcosine ethyl ester 
• 76387-70-7 (S)-3-amino-2-tert-butoxycarbonylaminopropionic acid 
• 52605-49-9 sarcosine ethyl ester hydrochloride 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 

Downstream Products

• 1276121-86-8 ({(S)-2-amino-3-[methyl-(2-nitrobenzenesulfonyl)amino]propionyl}methylamino) 
• 1276540-77-2 ({(S)-2-[(S)-5-({amino-[(Z)-2,2,4,6,7-pentamethyl-2,3-dihydro-benzofuran-5-sulfonylimino]-methyl}-amino)-2-tert-butoxycarbonylamino-pentanoylamino]-3-[methyl-(2-nitro-benzenesulfonyl)-amino]-propionyl}-methyl-amino)-acetic acid ethyl ester 
• 1276540-73-8 ({(S)-2-[(S)-2-amino-5-({amino-[(Z)-2,2,4,6,7-pentamethyl-2,3-dihydro-benzofuran-5-sulfonylimino]-methyl}-amino)-pentanoylamino]-3-[methyl-(2-nitro-benzenesulfonyl)-amino]-propionyl}-methyl-amino)-acetic acid ethyl ester 
• 1276540-74-9 ({(S)-2-[(S)-2-acetylamino-5-({amino-[(Z)-2,2,4,6,7-pentamethyl-2,3-dihydro-benzofuran-5-sulfonylimino]-methyl}-amino)-pentanoylamino]-3-[methyl-(2-nitro-benzenesulfonyl)-amino]-propionyl}-methyl-amino)-acetic acid ethyl ester 
• 1276540-73-8 ({(S)-2-[(S)-2-amino-5-({amino-[2,2,4,6,7-pentamethyl-2,3-dihydro-benzofuran-5-sulfonylimino]-methyl}-amino)-pentanoylamino]-3-[methyl-(2-nitro-benzenesulfonyl)-amino]-propionyl}-methyl-amino)-acetic acid ethyl ester 
• 1276540-74-9 ({(S)-2-[(S)-2-acetylamino-5-({amino-[2,2,4,6,7-pentamethyl-2,3-dihydro-benzofuran-5-sulfonylimino]-methyl}-amino)-pentanoylamino]-3-[methyl-(2-nitro-benzenesulfonyl)-amino]-propionyl}-methyl-amino)-acetic acid ethyl ester 
• 1276540-77-2 ({(S)-2-[(S)-5-({amino-[2,2,4,6,7-pentamethyl-2,3-dihydro-benzofuran-5-sulfonylimino]-methyl}-amino)-2-tert-butoxycarbonylamino-pentanoylamino]-3-[methyl-(2-nitro-benzenesulfonyl)-amino]-propionyl}-methyl-amino)-acetic acid ethyl ester 
• 1276121-85-7 ({(S)-2-tert-butoxycarbonylamino-3-[methyl-(2-nitrobenzenesulfonyl)amino]propionyl}methylamino)acetic acid ethyl ester 

Relevant articles and documents

An enzyme and its optional [...] modified ketone and inhibitor composition comprising (by machine translation)

PROBLEM TO BE SOLVED: ketone-containing acrylic misuse, abuse or overload is prevented for a new takable amt. provitamin drag pain. SOLUTION: a compound represented by the following formula is represented, in which the drag oxystyrene provitamin hydrocodone ketone-containing acrylic. Pre-selected drug profile is modified and the ketone and schisandrin [...] holding hung contg. compsn. method for administration to a patient. Selected drawing: no (by machine translation)

COMPOSITIONS COMPRISING ENZYME-CLEAVABLE PRODRUGS OF ACTIVE AGENTS AND INHIBITORS THEREOF

The present disclosure provides pharmaceutical compositions, and their methods of use, where the pharmaceutical compositions comprise a prodrug that provides enzymatically-controlled release of a drug and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the drug from the prodrug so as to attenuate enzymatic cleavage of the prodrug. The disclosure provides pharmaceutical compositions which comprise an enzyme inhibitor and a prodrug that contains an enzyme-cleavable moiety that, when cleaved, facilitates release of the drug.