1093966-37-0

Basic information

• Product Name: 2-amino-5-bromo-3-methylbenzonitrile
• Synonyms: 2-amino-5-bromo-3-methylbenzonitrile
• CAS NO: 1093966-37-0
• Molecular Weight: 211.061
• Mol File: 1093966-37-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-amino-5-bromo-3-methylbenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5-bromo-3-methylbenzonitrile(1093966-37-0)
• EPA Substance Registry System: 2-amino-5-bromo-3-methylbenzonitrile(1093966-37-0)

Safety Data

• Hazardous Substances Data: 1093966-37-0(Hazardous Substances Data)

Usage

Appearance

White to light yellow solid

Solubility

Sparingly soluble in water

Common uses

Intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes

Potential uses

Medicinal chemistry, development of new drugs targeting specific biological pathways
Potential use as a building block for the synthesis of other organic compounds
Versatile applications in organic chemistry and drug development.

Upstream product

• 922170-67-0 4-bromo-2-iodo-6-methylaniline 
• 557-21-1 zinc(II) cyanide 
• 583-75-5 4-Bromo-2-methylaniline 
• 69797-49-5 2-amino-3-methylbenzonitrile 

Relevant articles and documents

Discovery of a series of 1H-pyrrolo[2,3-b]pyridine compounds as potent TNIK inhibitors

In an in-house screening, 1H-pyrrolo[2,3-b]pyridine scaffold was found to have high inhibition on TNIK. Several series of compounds were designed and synthesized, among which some compounds had potent TNIK inhibition with IC50 values lower than 1 nM. Some compounds showed concentration-dependent characteristics of IL-2 inhibition. These results provided new applications of TNIK inhibitors and new prospects of TNIK as a drug target.

Arylpyrazol ester compound and synthesis method and application thereof

The invention relates to an arylpyrazol ester compound and a synthesis method and application thereof. The compound is applied to a pesticide intermediate. The synthesis method of the compound comprises the following steps: 1)taking 2-amino-3-methyl benzonitrile as a raw material, and reacting with bromide to obtain 2-amino-5-bromo-3-methyl benzonitrile; 2) dehydrogenizing the 2-amino-5-bromo-3-methyl benzonitrile to obtain 2,2'-(diazene-1,2-diyl)bis(5-bromo-3-methyl benzonitrile); 3) performing a reaction on the 2,2'-(diazene-1,2-diyl)bis(5-bromo-3-methyl benzonitrile) with ethyl alcohol to obtain the compound. Compared with the prior art, according to the arylpyrazol ester compound and the synthesis method and application thereof, the arylpyrazol ester compound 5-bromo-2-(5-bromo-7-methyl-3-ethoxycarbonyl-2H-indazole-2-yl)-3-methyl benzonitrile is synthesized by taking the 2-amino-3-methyl benzonitrile as the raw material through three steps of reaction; the synthetic process of the compound is simple; the operation steps are simplified; the generation of three wastes (waste gas, waste water and industrial residue) substances is reduced; relatively high product purity is realized.