922170-67-0Relevant articles and documents
Preparation method of 5-bromo-7-methylindole
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Paragraph 0061-0068; 0083-0090; 0105-0112; 0127-0134, (2021/07/01)
The invention discloses a preparation method of 5-bromo-7-methylindole. The structure of an intermediate corresponds to a formula V. The preparation method comprises the following steps: using 4-bromo-2-methylaniline as an initial raw material, and carryi
Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay
Knoepfel, Thomas,Nimsgern, Pierre,Jacquier, Sébastien,Bourrel, Marjorie,Vangrevelinghe, Eric,Glatthar, Ralf,Behnke, Dirk,Alper, Phil B.,Michellys, Pierre-Yves,Deane, Jonathan,Junt, Tobias,Zipfel, Géraldine,Limonta, Sarah,Hawtin, Stuart,Andre, Cedric,Boulay, Thomas,Loetscher, Pius,Faller, Michael,Blank, Jutta,Feifel, Roland,Betschart, Claudia
, p. 8276 - 8295 (2020/08/24)
Inappropriate activation of endosomal TLR7 and TLR8 occurs in several autoimmune diseases, in particular systemic lupus erythematosus (SLE). Herein, the development of a TLR8 antagonist competition assay and its application for hit generation of dual TLR7
ARYL, HETEROARY, AND HETEROCYCLIC PHARMACEUTICAL COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS
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Page/Page column 638; 639, (2018/09/21)
Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.