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953410-86-1

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953410-86-1 Usage

General Description

1H-Indazole, 5-bromo-7-iodo- is a chemical compound with the molecular formula C7H4BrIN2. It is a derivative of indazole, a heterocyclic aromatic organic compound. 1H-Indazole, 5-bromo-7-iodo- is a yellow solid at room temperature and is sparingly soluble in water. 1H-Indazole, 5-bromo-7-iodo- is commonly used as a building block in organic synthesis and is also known for its potential pharmacological activities. It has been studied for its use in the development of pharmaceutical drugs and as a substrate for various chemical reactions in the laboratory. Additionally, it has been investigated for its potential as a catalyst in organic reactions.

Check Digit Verification of cas no

The CAS Registry Mumber 953410-86-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,3,4,1 and 0 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 953410-86:
(8*9)+(7*5)+(6*3)+(5*4)+(4*1)+(3*0)+(2*8)+(1*6)=171
171 % 10 = 1
So 953410-86-1 is a valid CAS Registry Number.

953410-86-1Downstream Products

953410-86-1Relevant articles and documents

Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay

Knoepfel, Thomas,Nimsgern, Pierre,Jacquier, Sébastien,Bourrel, Marjorie,Vangrevelinghe, Eric,Glatthar, Ralf,Behnke, Dirk,Alper, Phil B.,Michellys, Pierre-Yves,Deane, Jonathan,Junt, Tobias,Zipfel, Géraldine,Limonta, Sarah,Hawtin, Stuart,Andre, Cedric,Boulay, Thomas,Loetscher, Pius,Faller, Michael,Blank, Jutta,Feifel, Roland,Betschart, Claudia

, p. 8276 - 8295 (2020/08/24)

Inappropriate activation of endosomal TLR7 and TLR8 occurs in several autoimmune diseases, in particular systemic lupus erythematosus (SLE). Herein, the development of a TLR8 antagonist competition assay and its application for hit generation of dual TLR7

ARYL, HETEROARY, AND HETEROCYCLIC PHARMACEUTICAL COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS

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Page/Page column 638; 639; 640, (2018/09/21)

Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

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