109596-92-1

Basic information

• Product Name: N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-2,3-dimethoxybenzamide
• Synonyms: N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-2,3-dimethoxybenzamide
• CAS NO: 109596-92-1
• Molecular Weight: 329.353
• Mol File: 109596-92-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-2,3-dimethoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-2,3-dimethoxybenzamide(109596-92-1)
• EPA Substance Registry System: N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-2,3-dimethoxybenzamide(109596-92-1)

Safety Data

• Hazardous Substances Data: 109596-92-1(Hazardous Substances Data)

Upstream product

• 7228-38-8 5-chloro-1,3-benzodioxole 
• 274-09-9 Methylenedioxybenzene 
• 1521-38-6 2,3-dimethoxybenzoic acid 
• 1484-85-1 3,4-methylenedioxyphenylethylamine 

Downstream Products

• 1022085-99-9 C₂₁H₂₁NO₈ 
• 71700-15-7 12b-hydroxy-9,10-dimethoxy-5H-[1,3]dioxolo[4'',5'':4',5']benzo[1',2':4,5]azepino[2,1-a]isoindole-8,13(6H,12bH)-dione 
• 1075231-76-3 C₁₈H₁₈INO₅ 
• 1537904-55-4 11b-(2,3-dimethoxyphenyl)-5,6-dihydro-2H-[1,3]dioxolo[4,5-g]oxazolo[2,3-a]isoquinoline-2,3(11bH)-dione 
• 1075231-74-1 C₂₃H₂₇NO₅ 
• 102028-61-5 5-(2,3-dimethoxy-phenyl)-[1,3]dioxolo[4,5-g]isoquinoline 
• 101734-53-6 5-(2,3-dimethoxy-phenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline 

Relevant articles and documents

Synthesis of important intermediate of berberine

The invention discloses synthesis of an important intermediate of berberine. A synthesis method comprises the following steps: reacting 1,3-benzodioxole with chlorine in an organic solvent to produce5-chloro-1,3-benzodioxole; reacting 5-chloro-1,3-benzodioxole with a magnesium rod in an ether solvent to produce a Grignard reagent; reacting 2,3-dimethoxybenzoic acid with aziridine in an organic solvent under the action of a dehydrating agent to produce 1-aziridine-2,3-dimethoxyphenylethanone; and under the action of the Grignard reagent, subjecting 1-aziridine-2,3-dimethoxyphenylethanone to ring opening so as to obtain the important intermediate of berberine, i.e., N-(2-(benzo[d][1,3]dioxin-5-yl)ethyl)-2,3-dimethoxybenzamide. The synthesis method is mild in reaction conditions and simple to operate.

A concise synthesis of chilenine via a sequential reaction process

A new short synthesis of chilenine has been achieved in two steps. The precursor amide was readily prepared by the condensation of the corresponding amine and acid. Treatment of the amide with oxalyl chloride in the presence of AlCl3 at room te