274-09-9 Usage
Description
1,3-Benzodioxole, a benzodioxole consisting of a benzene ring substituted by a methylenedioxy group, is a clear colorless to light yellow liquid that is insoluble in acids. It is widely found in plant products and has demonstrated potent antioxidant and antibacterial activities. Recent studies have shown that 1,3-benzodioxole derivatives exhibit cytotoxic activity against several human tumor cell lines, including human colon carcinoma cells and multidrug-resistant nasopharyngeal carcinoma cells, with no cytotoxic effects observed at a concentration of 10^-4 M.
Uses
Used in Gemological Applications:
1,3-Benzodioxole is used as a gemological stimulant detector for identifying and analyzing gemstones.
Used in Perfumery:
1,3-Benzodioxole is used as a precursor in the perfume industry, contributing to the creation of various fragrances.
Used in Photochemistry:
1,3-Benzodioxole serves as a photo initiator, playing a crucial role in the photopolymerization process, particularly in the dental composite resin industry.
Used in Agrochemicals:
1,3-Benzodioxole is utilized as a precursor in the synthesis of various agrochemicals, contributing to the development of pesticides and other agricultural products.
Used in Pharmaceutical Industry:
1,3-Benzodioxole is an intermediate in the synthesis of drugs such as oxolinic acid, cinoxacin, and miloxacin, which are used for treating various medical conditions.
Used in Drug Oxidation:
1,3-Benzodioxole belongs to methylenedioxyphenyl (MDP) compounds that regulate cytochrome P450-dependent drug oxidation, which is essential in the process of eliminating drugs from the body.
Used in Organic Synthesis:
1,3-Benzodioxole is an important organic intermediate (building block) for synthesizing substituted methylenedioxybenzene products, which find applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 274-09-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,7 and 4 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 274-09:
(5*2)+(4*7)+(3*4)+(2*0)+(1*9)=59
59 % 10 = 9
So 274-09-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H6O2/c1-2-4-7-6(3-1)5-8-9-7/h1-4H,5H2
274-09-9Relevant articles and documents
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Dallacker,Binsack
, p. 492 (1961)
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Transition metal catalyzed preparation of Grignard compounds
Bogdanovi, Borislav,Schwickardi, Manfred
, p. 4610 - 4612 (2000)
The "inorganic Grignard reagents", in particular those of 1, have surprisingly been shown to be efficient homogeneous catalysts for the conversion of inactive chloroarenes and heteroarenes (via the aryl-iron intermediate 2) into the corresponding Grignard
Mechanistic studies into visible light-driven carboxylation of aryl halides/triflates by the combined use of palladium and photoredox catalysts
Caner, Joaquim,Iwasawa, Nobuharu,Martin, Ruben,Murata, Kei,Shimomaki, Katsuya,Toriumi, Naoyuki
supporting information, p. 1846 - 1853 (2021/08/13)
The reaction mechanism of palladium-catalyzed visible light-driven carboxylation of aryl halides and triflates with a photoredox catalyst was examined in detail. Experimental and theoretical studies indicated that the active species for photoredox- catalyzed reduction was cationic ArPd(II)+ species to generate nucleophilic ArPd(I) or its further reduced ArPd(0)- species, which reacted with CO2 to give carboxylic acids. Hydrodehalogenated compounds, main byproducts in this carboxylation, were thought to be generated by protonation of these reduced species.
A method of synthesis of piperonolamine
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Paragraph 0144-0147; 0157-0160, (2022/01/07)
The present invention belongs to the field of organic chemical synthesis, specifically relates to a synthesis method of piperine, comprising: using catechol as a raw material to prepare piperonaldehyde; β - nitro-3,4-dioxenosylstyrene prepared with piperonaldehyde; β - nitro -3,4-dioxenesimethylenestyrene to obtain piperine ethylamine. Among them, the preparation of piperaldehyde from catechol as raw materials includes two ways: (1) catechol→3,4-dihydroxymandelic acid→3,4-dihydroxybenzaldehyde→ piperaldehyde; (2) catechol→ piperine ring → piperine. The raw materials used in the present invention are safe and readily available, low cost; the reaction conditions are mild, the operation is simple, the chemical yield is high, and the intermediate reagents are easy to recover; suitable for industrial production.