4755-77-5 Usage
Description
Ethyl oxalyl monochloride, also known as Ethyl chlorooxoacetate, is a clear liquid chemical compound that serves as a versatile reactant in various organic synthesis processes. It is particularly useful in the production of 2-oxo-3-alkenoic esters, alpha-keto esters, and oxyoxalamide derivatives.
Uses
Used in Pharmaceutical Industry:
Ethyl oxalyl monochloride is used as a reactant for the synthesis of oxyoxalamide derivatives, which act as epoxide hydrolase inhibitors. These inhibitors play a crucial role in the development of pharmaceuticals targeting various diseases and conditions.
Used in Chemical Synthesis:
Ethyl oxalyl monochloride is used as a reactant for the synthesis of various chemical compounds, including:
1. 2-oxo-3-alkenoic esters and alpha-keto esters, which are important intermediates in the production of various organic compounds.
2. Functionalized 3-pyrolin-2-ones, which are valuable building blocks in the synthesis of complex organic molecules.
3. Substituted arylglyoxylic acids via Friedel–Crafts acylation, a widely used method for the synthesis of aromatic compounds.
4. Substituted 9,10-phenanthrenequinones, which are used in the production of dyes and pigments.
5. Quinoxalinone derivatives, which have potential applications in the development of pharmaceuticals and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 4755-77-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,7,5 and 5 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4755-77:
(6*4)+(5*7)+(4*5)+(3*5)+(2*7)+(1*7)=115
115 % 10 = 5
So 4755-77-5 is a valid CAS Registry Number.
InChI:InChI=1/C4H5ClO3/c1-2-8-4(7)3(5)6/h2H2,1H3
4755-77-5Relevant articles and documents
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Rhoads,S.J.,Michel,R.E.
, p. 585 - 591 (1963)
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Synthesis and application of oxalic acid monoester derivatives
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Paragraph 0015-0018, (2020/12/08)
The invention relates to synthesis and application of oxalic acid monoester-containing compounds as shown in a general formula (I) which is described in the specification. The compounds represent a broad-spectrum efficient insecticidal and bactericidal agent structure type. The oxalic acid monoester-containing compounds can well control aphids, plutella xylostella and spodoptera exigua when used as novel insecticidal bactericides; the compounds can also be used for preventing and treating cucumber brown blotch, cucumber bacterial angular leaf spot, cucumber fusarium wilt, cucumber downy mildew, cucumber powdery mildew, tomato bacterial leaf spot and rice sheath blight. R in the general formula (I) is as defined in the specification.
Silver-Catalyzed Cyclization of Propargylic Amides to Oxazolines
Wong, Valerie H. L.,White, Andrew J. P.,Hor,Hii
supporting information, p. 3943 - 3948 (2016/01/25)
A ligand-accelerated effect is observed in the cyclization of propargylic amides catalyzed by bis(pyridyl)silver(I) complexes, with an unexpected reversal of electronic demand to the analogous NH addition reaction. The catalyst was found to be effective for internal alkyne substrates, offering exclusive selectivity for the 5-exo-dig product. Differences in selectivity profile between gold- and silver-catalyzed processes are highlighted and discussed.