41374-72-5

Basic information

• Product Name: Acetic acid, oxo(2-pyridinylamino)-, ethyl ester
• CAS NO: 41374-72-5
• Molecular Formula: C9H10N2O3
• Molecular Weight: 194.19
• Mol File: 41374-72-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Acetic acid, oxo(2-pyridinylamino)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, oxo(2-pyridinylamino)-, ethyl ester(41374-72-5)
• EPA Substance Registry System: Acetic acid, oxo(2-pyridinylamino)-, ethyl ester(41374-72-5)

Safety Data

• Hazardous Substances Data: 41374-72-5(Hazardous Substances Data)

Usage

General Description

Acetic acid, oxo(2-pyridinylamino)-, ethyl ester, also known as ethyl 2-(2-pyridyl)glyoxylate, is a chemical compound with the molecular formula C9H9NO3. It is an ethyl ester of 2-(2-pyridyl)glyoxylic acid and is commonly used as an intermediate in the production of pharmaceuticals, agrochemicals, and dyes. It is a colorless to light yellow liquid with a fruity odor and is soluble in organic solvents. Acetic acid, oxo(2-pyridinylamino)-, ethyl ester is often used as a reagent in organic synthesis and can also be found in some flavor and fragrance products. Acetic acid, oxo(2-pyridinylamino)-, ethyl ester is a hazardous chemical and should be handled with care. It may cause irritation to the skin, eyes, and respiratory system upon contact or inhalation, and ingestion may lead to nausea, vomiting, and abdominal pain. Proper safety precautions and handling procedures should be followed when working with this compound.

Upstream product

• 504-29-0 2-aminopyridine 
• 4755-77-5 Ethyl oxalyl chloride 

Relevant articles and documents

A new, one-pot, three-component synthesis of 4H-pyrido[1,2-a]pyrimidines, 4H-pyrimido[1,2-a]pyrimidines, and 4H-pyrazino[1,2-a]pyrimidines

A new, one-pot and three-component synthesis of 4H-pyrido[1,2-a]pyrimidines, 4H-pyrimido[1,2-a]pyrimidines, and 4H-pyrazino[1,2-a]pyrimidines is described. The reactive 1:1 zwitterionic intermediate, formed by the addition of isocyanides to dialkyl acetyl

Discovery of Cytochrome P450 4F11 Activated Inhibitors of Stearoyl Coenzyme A Desaturase

Stearoyl-CoA desaturase (SCD) catalyzes the first step in the conversion of saturated fatty acids to unsaturated fatty acids. Unsaturated fatty acids are required for membrane integrity and for cell proliferation. For these reasons, inhibitors of SCD represent potential treatments for cancer. However, systemically active SCD inhibitors result in skin toxicity, which presents an obstacle to their development. We recently described a series of oxalic acid diamides that are converted into active SCD inhibitors within a subset of cancers by CYP4F11-mediated metabolism. Herein, we describe the optimization of the oxalic acid diamides and related N-acyl ureas and an analysis of the structure-activity relationships related to metabolic activation and SCD inhibition.

Pyridyl oxamic acid derivatives and use in the prevention of allergic reactions

Anti-allergic agents of aromatic and heterocyclic oxamic acid derivation present the following formula: STR1 in which A is a member selected from the group consisting of 2-thiazolyl, 2-pyridyl, 2-pyridyl-N-oxide, 6-(lower)alkyl-2-pyridyl, 3-cyano-2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 2-pyrazinyl, α-naphthyl, βnaphthyl, phenyl, 2,6-dichlorophenyl, and substituted phenyl moieties containing from one to three substituents in any of the 2,3,4 and 5 positions of the phenyl ring, independently selected from the group consisting of lower alkyl, lower alkylthio, lower alkylsulfinyl, lower alkoxy, hydroxy(lower)-alkoxy, 2-(lower alkoxy oxalyloxy) ethoxy, benzyloxy, N-mono-and di-lower alkylamino(lower)-alkoxy, halo, sulfamyl, polyhalo(lower)alkyl, carbamyl, N-lower alkylcarbamyl, nitro, mono-and di-lower alkylamino, phenylazo, carboxy, lower alkylcarbonyl, cyano, carb(lower)alkoxy, phenoxy(lower)alkoxy, lower alkoxyoxalamido and lower alkoxyoxalamidophenoxy radicals; B, when taken alone, is a member selected from the group consisting of --OH, lower alkoxy, --NH2, --NHOH, cyclohexyloxy and phenoxy; and Y is a member selected from the group consisting of oxygen and when taken with B and the carbon atom to which they are attached, forms the moiety STR2