54249-44-4

Basic information

• Product Name: N-(2-Carbamoyl-3-methoxyphenyl)oxamidic acid ethyl ester
• Synonyms: N-(2-Carbamoyl-3-methoxyphenyl)oxamidic acid ethyl ester;Wy-16922
• CAS NO: 54249-44-4
• Molecular Formula: C₁₂H₁₄N₂O₅
• Molecular Weight: 266.25
• Mol File: 54249-44-4.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Density: 1.319g/cm³
• Refractive Index: 1.58
• CAS DataBase Reference: N-(2-Carbamoyl-3-methoxyphenyl)oxamidic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Carbamoyl-3-methoxyphenyl)oxamidic acid ethyl ester(54249-44-4)
• EPA Substance Registry System: N-(2-Carbamoyl-3-methoxyphenyl)oxamidic acid ethyl ester(54249-44-4)

Safety Data

• Hazardous Substances Data: 54249-44-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H14N2O5/c1-3-19-12(17)11(16)14-7-5-4-6-8(18-2)9(7)10(13)15/h4-6H,3H2,1-2H3,(H2,13,15)(H,14,16)

Upstream product

• 1591-38-4 2-amino-6-methoxybenzamide 
• 4755-77-5 Ethyl oxalyl chloride 
• 603-12-3 2,6-dinitrobenzoic acid 
• 38469-85-1 2-methoxy-6-nitrobenzonitrile 
• 35213-00-4 2,6-dinitrobenzonitrile 
• 63365-14-0 2-amino-6-(1-piperidinyl)benzonitrile 
• 63365-13-9 2-nitro-6-(1-piperidinyl)benzonitrile 

Downstream Products

• 54166-74-4 2'-carbamoyl-3'-methoxyoxanilic acid 
• 54166-75-5 N-(2-Carbamoyl-3-methoxyphenyl)oxamide 

Relevant articles and documents

SUBSTITUTED 2- AMIDOQUINAZOL-4-ONES AS MATRIX METALLOPROTEINASE-13 INHIBITORS

The present invention provides a novel amide derivative having a matrix metalloproteinase inhibitory activity, and useful as a pharmaceutical agent, which is a compound represented by the formula (I) wherein ring A is an optionally substituted, nitrogen containing heterocycle, ring B is an optionally substituted monocyclic homocycle or an optionally substituted monocyclic heterocycle, Z is N or NR1 (R1 is a hydrogen atom or an optionally substituted hydrocarbon group), is a single bond or a double bond, R2 is a hydrogen atom or an optionally substituted hydrocarbon group, X is an optionally substituted spacer having 1 to 6 atoms, ring C is (1) an optionally substituted homocycle or (2) an optionally substituted heterocycle other than a ring represented by (II) (X′ is S, O, SO, or CH2), and at least one of ring B and ring C has substituent(s), provided that N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]2 hydroxypropyl}5,6 dimethyl 4 oxo 1,4 dihydrothieno[2,3-d]pyrimidine-2-carboxamide is excluded, or a salt thereof.

Oxamic acid derivatives

Anti-allergic agents of aromatic and heterocyclic oxamic acid derivation present the following formula: STR1 in which A is a member selected from the group consisting of 2-thiazolyl, 2-pyridyl, 2-pyridyl-N-oxide, 6-(lower)alkyl-2-pyridyl, 3-cyano-2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 2-pyrazinyl, α-naphthyl, β-naphthyl, phenyl, 2,6-di-chlorophenyl, and substituted phenyl moieties containing from one to three substituents in any of the 2,3,4 and 5 positions of the phenyl ring, independently selected from the group consisting of lower alkyl, lower alkylthio, lower alkylsulfinyl, lower alkoxy, hydroxy(lower)alkoxy, 2-(lower alkoxy oxalyloxy) ethoxy, benzyloxy, N-mono-and di-lower alkylamino(lower)alkoxy, halo, sulfamyl, polyhalo(lower)alkyl, carbamyl, N-lower alkylcarbamyl, nitro, mono-and di-lower alkylamino, phenylazo, carboxy, lower alkylcarbonyl, cyano, carb(lower)alkoxy, phenoxy(lower)alkoxy, lower alkoxyoxalamido and lower alkoxyoxalamidophenoxy radicals; B, when taken alone, is a member selected from the group consisting of --OH, lower alkoxy, --NH2, --NHOH, cyclohexyloxy and phenoxy; and Y is a member selected from the group consisting of oxygen and when taken with B and the carbon atom to which they are attached, forms the moiety STR2

Antisecretory oxamic acid esters

Variously substituted oxanilic acid esters possessing anti-secretary activity are useful anti-ulcer agents.