164219-31-2

Basic information

• Product Name: ethyl (S)-2-oxo-2-((1-phenylethyl)amino)acetate
• Synonyms: ethyl (S)-2-oxo-2-((1-phenylethyl)amino)acetate
• CAS NO: 164219-31-2
• Molecular Weight: 221.256
• Mol File: 164219-31-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: ethyl (S)-2-oxo-2-((1-phenylethyl)amino)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (S)-2-oxo-2-((1-phenylethyl)amino)acetate(164219-31-2)
• EPA Substance Registry System: ethyl (S)-2-oxo-2-((1-phenylethyl)amino)acetate(164219-31-2)

Safety Data

• Hazardous Substances Data: 164219-31-2(Hazardous Substances Data)

Upstream product

• 79-37-8 oxalyl dichloride 
• 64-17-5 ethanol 
• 642442-03-3 N-(11H-dibenzo[b,e]azepin-6-ylmethyl)-N-[(1'S)-1'-phenylethyl]amine 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 4755-77-5 Ethyl oxalyl chloride 
• 333319-62-3 1-Phenylethylamine oxalamic acid ethyl ester 

Downstream Products

• 6623-43-4 (S)-(-)-N-(2-hydroxyethyl)-α-methylbenzylamine 
• 164219-32-3 (S)-2-oxo-2-((1-phenylethyl)amino)acetic acid 
• 889765-38-2 (S)-3-Methyl-2-[2-((S)-1-phenyl-ethylamino)-ethylamino]-butan-1-ol 
• 817168-33-5 4-((S)-1-Phenyl-ethyl)-morpholine-2,3-dione 
• 207690-58-2 ((S)-1-Phenyl-ethyl)-(2-triisopropylsilanyloxy-ethyl)-amine 
• 207690-61-7 (1S,3R)-3-(3-indolylmethyl)-1-(1-phenylethyl)piperazin-2-one 
• 207690-60-6 (R)-2-Amino-N-(2-hydroxy-ethyl)-3-(1H-indol-3-yl)-N-((S)-1-phenyl-ethyl)-propionamide 
• 207690-59-3 (1R,1'S)-{2-(3-indolyl)-1-[(1-phenylethyl)-(2-triisopropylsilanyloxyethyl)-carbamoyl]-ethyl}carbamic acid benzyl ester 
• 17397-44-3 (1S,2R,5S)-2-isopropyl-5-methylcyclohexyl ((S)-1-phenylethyl)carbamate 
• 14649-03-7 (S)-phenylethyl isocyanate 

Relevant articles and documents

Supporting-Electrolyte-Free Anodic Oxidation of Oxamic Acids into Isocyanates: An Expedient Way to Access Ureas, Carbamates, and Thiocarbamates

We report a new electrochemical supporting-electrolyte-free method for synthesizing ureas, carbamates, and thiocarbamates via the oxidation of oxamic acids. This simple, practical, and phosgene-free route includes the generation of an isocyanate intermediate in situ via anodic decarboxylation of an oxamic acid in the presence of an organic base, followed by the one-pot addition of suitable nucleophiles to afford the corresponding ureas, carbamates, and thiocarbamates. This procedure is applicable to different amines, alcohols, and thiols. Furthermore, when single-pass continuous electrochemical flow conditions were used and this reaction was run in a carbon graphite Cgr/Cgr flow cell, urea compounds could be obtained in high yields within a residence time of 6 min, unlocking access to substrates that were inaccessible under batch conditions while being easily scalable.

Syntheses of morpholine-2,3-diones and 2-hydroxymorpholin-3-ones: Intermediates in the synthesis of aprepitant

The preparation of morpholine-2,3-diones and 2-hydroxymorpholin-3-ones from N-substituted β-amino alcohols is reported. These were useful intermediates in the synthesis and development of aprepitant.

The Use of Heterocycles for the Conformational Restriction of Biologically Active Peptoids

A series of piperazinone ring systems have been synthesized as a means of evaluating the effect of conformational restriction of high affinity non-peptide NK1, NK3 and CCK-B receptor ligands.The synthesis of the targeted heterocycles is described along with a discussion of their affinities for their respective receptor types.